4-(CYCLOPROPYLAMINO)-3-NITROPYRIDINE

Base Information

• Chemical Name: 4-(CYCLOPROPYLAMINO)-3-NITROPYRIDINE
• CAS No.: 380605-28-7
• Molecular Formula: C8H9 N3 O2
• Molecular Weight: 179.178
• Hs Code.: 2933399090
• Mol file: 380605-28-7.mol

Synonyms:Cyclopropyl(3-nitropyridin-4-yl)amine

Chemical Property of 4-(CYCLOPROPYLAMINO)-3-NITROPYRIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 345.645oC at 760 mmHg
• Flash Point: 162.841oC
• PSA: 70.74000
• Density: 1.453
• LogP: 2.16030
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

N-Cyclopropyl-3-nitropyridin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(CYCLOPROPYLAMINO)-3-NITROPYRIDINE

There total 2 articles about 4-(CYCLOPROPYLAMINO)-3-NITROPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxy-3-nitro-pyridine (31872-62-5) + Cyclopropylamine (765-30-0) → N-cyclopropyl-3-nitropyridin-4-amine (380605-28-7)

Guidance literature:

at 100 ℃; Sealed tube; Inert atmosphere;

DOI:10.1021/op049899l

Reference yield:

4-hydroxy-3-nitropyridine (5435-54-1) → N-cyclopropyl-3-nitropyridin-4-amine (380605-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / 1,2-dichloro-ethane / 4 h / 80 - 85 °C / Inert atmosphere

1.2: 1 h / 0 - 65 °C / Inert atmosphere

2.1: 100 °C / Sealed tube; Inert atmosphere

With trichlorophosphate; In 1,2-dichloro-ethane;

DOI:10.1021/op049899l

Reference yield: 97.0%

N-cyclopropyl-3-nitropyridin-4-amine (380605-28-7) → N4-cyclopropylpyridin-3,4-diamine (146950-68-7)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; water; for 4h; under 2585.81 Torr; Inert atmosphere;

DOI:10.1021/op049899l

upstream raw materials:

4-methoxy-3-nitro-pyridine

Cyclopropylamine

4-hydroxy-3-nitropyridine

Downstream raw materials:

N⁴-cyclopropylpyridin-3,4-diamine

4-(5-bromo-2-((1-cyclopropyl-2-oxo-1H-imidazo[4,5-c]pyridin-3(2H)-yl)methyl)-1H-indol-1-yl)butyl 4-methylbenzensulfonate

C₁₁H₁₃N₃O₄

Refernces

• 1、 -. "Targeting human La and its precursor compound of the protein in the preparation of anti-hepatitis b virus use in medicine". Paragraph 0055; 0059; 0060. . Retrieved 2017/01/12.
• 2、 -. "INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS". Paragraph 0092; 0096-0097. . Retrieved 2013/10/22.