Methyl 3-amino-2,2-dimethylpropanoate

Base Information

• Chemical Name: Methyl 3-amino-2,2-dimethylpropanoate
• CAS No.: 25307-82-8
• Molecular Formula: C6H13 N O2
• Molecular Weight: 131.175
• Hs Code.: 2922499990
• DSSTox Substance ID: DTXSID70534761
• Wikidata: Q82408734
• Mol file: 25307-82-8.mol

Synonyms:Methyl 3-amino-2,2-dimethylpropanoate;25307-82-8;PROPANOIC ACID, 3-AMINO-2,2-DIMETHYL-, METHYL ESTER;SCHEMBL291019;3-AMINO-2,2-DIMETHYL-PROPANOIC ACID METHYL ESTER;DTXSID70534761;YAVPDSQCYSZORP-UHFFFAOYSA-N;AMY19450;Methyl3-amino-2,2-dimethylpropanoate;AKOS005263910;AB64273;A15421;EN300-113854;3-AMINO-2,2-DIMETHYL-PROPIONIC ACID METHYL ESTER

Chemical Property of Methyl 3-amino-2,2-dimethylpropanoate

Chemical Property:

• Boiling Point: 63-64℃ (14 Torr)
• PKA: 8.76±0.10(Predicted)
• PSA: 52.32000
• Density: 0.973±0.06 g/cm3(Predicted)
• LogP: 0.84460
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 131.094628657
• Heavy Atom Count: 9
• Complexity: 110

Purity/Quality:

98% ^*data from raw suppliers

Methyl3-amino-2,2-dimethylpropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(CN)C(=O)OC

Technology Process of Methyl 3-amino-2,2-dimethylpropanoate

There total 15 articles about Methyl 3-amino-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + aminopivalic acid (19036-43-2) → methyl 3-amino-2,2-dimethylpropionate (25307-82-8)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 20h;

Reference yield: 80.0%

2,2-dimethyl-N,N-bis(trimethylsilyl)-β-alanine methyl ester (94143-84-7) → methyl 3-amino-2,2-dimethylpropionate (25307-82-8)

Guidance literature:

With methanol; for 24h; Heating;

Reference yield: 75.0%

methyl 2,2-dimethyl-3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoate (259794-51-9) → methyl 3-amino-2,2-dimethylpropionate (25307-82-8)

Guidance literature:

With hydrazine; In methanol; at 65 ℃; for 5h;

upstream raw materials:

methanol

aminopivalic acid

diazomethane

2,2-dimethyl-N,N-bis(trimethylsilyl)-β-alanine methyl ester

Downstream raw materials:

C₂₄H₂₆N₂O₄

aminopivalinamide

3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

methyl 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoate

Refernces

• 1、 -. "METHOD FOR THE PREPARATION OF OMEGA-AMINO-ALKANEAMIDES AND OMEGA-AMINO-ALKANETHIOAMIDES AS WELL AS INTERMEDIATES OF THIS METHOD". Page/Page column 19. . Retrieved 2012/02/05.
• 2、 -. "Method for the Production of Aminoalkane Acid Amides". Page/Page column 4-5. . Retrieved 2009/01/20.