6-Bromo-2-methoxyquinoline

Base Information

• Chemical Name: 6-Bromo-2-methoxyquinoline
• CAS No.: 99455-05-7
• Molecular Formula: C10H8BrNO
• Molecular Weight: 238.084
• Hs Code.: 2933499090
• European Community (EC) Number: 640-226-2
• DSSTox Substance ID: DTXSID40443139
• Nikkaji Number: J515.837K
• Wikidata: Q82260850
• Mol file: 99455-05-7.mol

Synonyms:6-Bromo-2-methoxyquinoline;99455-05-7;2-methoxy-6-bromoquinoline;QUINOLINE, 6-BROMO-2-METHOXY-;6-bromo-2-methoxy-quinoline;MFCD11847805;SCHEMBL727654;6-bromo-2-(methyloxy)quinoline;DTXSID40443139;KBTKKEMYFUMFSJ-UHFFFAOYSA-N;AMY25891;ZDA45505;AKOS015904661;MB10111;PS-7625;BL002346;SY065637;CS-0035482;FT-0759201;EN300-1428636;A846027;J-518333;Z1269176462

Chemical Property of 6-Bromo-2-methoxyquinoline

Chemical Property:

• Melting Point: 87-89℃
• Boiling Point: 312.635 °C at 760 mmHg
• PKA: 2.39±0.43(Predicted)
• Flash Point: 142.877 °C
• PSA: 22.12000
• Density: 1.517 g/cm³
• LogP: 3.00590
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 236.97893
• Heavy Atom Count: 13
• Complexity: 176

Purity/Quality:

98%Min ^*data from raw suppliers

6-Bromo-2-methoxyquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC2=C(C=C1)C=C(C=C2)Br
• Uses: 6-Bromo-2-methoxyquinoline is a reagent used for preparing diarylquinoline derivatives.

Technology Process of 6-Bromo-2-methoxyquinoline

There total 14 articles about 6-Bromo-2-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 6-bromo-2-chloroquinoline (1810-71-5) + sodium methylate (124-41-4) → 2-methoxy-6-bromoquinoline (99455-05-7)

Guidance literature:

at 80 ℃; for 16h;

Reference yield: 95.0%

6-bromo-2-chloroquinoline (1810-71-5) + sodium methylate (124-41-4) → 2-methoxy-6-bromoquinoline (99455-05-7)

Guidance literature:

In methanol; for 16h; Reflux;

Reference yield: 77.0%

methanol (67-56-1) + 6-bromo-2-chloroquinoline (1810-71-5) → 2-methoxy-6-bromoquinoline (99455-05-7)

Guidance literature:

With sodium methylate; for 17h; Heating;

DOI:10.1016/S0223-5234(00)01167-3

upstream raw materials:

2-methoxy-quinoline

6-bromo-2-chloroquinoline

sodium methylate

methanol

Downstream raw materials:

6-(2,6-Dimethyl-pyridin-3-yl)-2-methoxy-quinoline

2-Methoxy-6-(2-methyl-pyridin-3-yl)-quinoline

EB₄₀

N,N-diisopropyl-4-(2-oxo-1,2-dihydro-quinolin-6-yl)-benzamide

Refernces

• 1、 -. "INHIBITORS OF FATTY ACID AMIDE HYDROLASE". Paragraph 1019. . Retrieved 2016/01/15.
• 2、 -. "6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW MAO INHIBITORS AND IMIDAZOLINE RECEPTOR LIGANDS". Page/Page column 42. . Retrieved 2010/01/12.