2-Pyrimidinamine, 5-ethoxy- (9CI)

Base Information

• Chemical Name: 2-Pyrimidinamine, 5-ethoxy- (9CI)
• CAS No.: 39268-74-1
• Molecular Formula: C6H9N3O
• Molecular Weight: 139.157
• Hs Code.: 2933599090
• Mol file: 39268-74-1.mol

Synonyms:Pyrimidine,2-amino-5-ethoxy- (6CI,7CI);2-Amino-5-ethoxypyrimidine;5-Ethoxy-2-pyrimidinamine;

Chemical Property of 2-Pyrimidinamine, 5-ethoxy- (9CI)

Chemical Property:

• Boiling Point: 316.88 °C at 760 mmHg
• Flash Point: 145.444 °C
• PSA: 61.03000
• Density: 1.173 g/cm³
• LogP: 1.03870
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

5-Ethoxy-2-pyrimidinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-Ethoxy-2-pyrimidinamine is an intermediate used to prepare triazolopyrimidine and imidazopyrimidine derivatives as inhibitors of PI3K/Akt pathway useful in the treatment of diseases. It is also used to prepare sulfonamide derivatives as angiotensin II receptor antagonists/PPARγ activators.

Technology Process of 2-Pyrimidinamine, 5-ethoxy- (9CI)

There total 1 articles about 2-Pyrimidinamine, 5-ethoxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-amino-5-ethoxypyrimidine (39268-74-1)

Guidance literature:

2-Amino-4,6-dichlor-5-aethoxy-pyrimidin, Zn-Pulver, KOH, Δ;

Reference yield: 58.0%

methyl (Z)-2-{[6-(2-cyanophenyl)pyridin-3-yl]methyl}-3-isobutylamide-2-hexenoate + 2-amino-5-ethoxypyrimidine (39268-74-1) → 2-{5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}benzonitrile (1400690-97-2)

Guidance literature:

2-amino-5-ethoxypyrimidine; With trimethylaluminum; In hexane; 1,2-dichloro-ethane; at 20 ℃; for 1.16667h; Inert atmosphere;

methyl (Z)-2-{[6-(2-cyanophenyl)pyridin-3-yl]methyl}-3-isobutylamide-2-hexenoate; In hexane; 1,2-dichloro-ethane; at 20 ℃; for 3h; Reflux;

Reference yield: 18.0%

(RS)-2-(4-bromo-3-fluorophenyl)-morpholine-4-carboxylic acid tert-butyl ester (1400997-38-7) + 2-amino-5-ethoxypyrimidine (39268-74-1) → (RS)-2-[4-(5-ethoxy-pyrimidin-2-ylamino)-3-fluoro-phenyl]-morpholine-4-carboxylic acid tert-butyl ester (1400997-42-3)

Guidance literature:

With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In 1,4-dioxane; at 120 ℃; for 16h; Inert atmosphere;

Downstream raw materials:

3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methylpyridin-2(1H)-one

4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

3-{4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

C₂₇H₂₁F₃N₄O₅S

Refernces