5-(4-FLUOROPHENYL)-2-PYRIDINAMINE

Base Information

• Chemical Name: 5-(4-FLUOROPHENYL)-2-PYRIDINAMINE
• CAS No.: 503536-73-0
• Molecular Formula: C11H9 F N2
• Molecular Weight: 188.204
• Hs Code.: 2933399090
• Mol file: 503536-73-0.mol

Synonyms:

Chemical Property of 5-(4-FLUOROPHENYL)-2-PYRIDINAMINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 320.611oC at 760 mmHg
• PKA: 6.19±0.26(Predicted)
• Flash Point: 147.7oC
• PSA: 38.91000
• Density: 1.218
• LogP: 3.05110
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-(4-Fluorophenyl)pyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(4-FLUOROPHENYL)-2-PYRIDINAMINE

There total 5 articles about 5-(4-FLUOROPHENYL)-2-PYRIDINAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-amino-5-iodopyridine (20511-12-0) + 4-fluoroboronic acid (1765-93-1) → 2-amino-5-(p-fluorophenyl)pyridine (503536-73-0)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 120 ℃;

DOI:10.1039/c8ra03697g

Reference yield: 83.0%

5-bromo-2-pyridylamine (1072-97-5) + 4-fluoroboronic acid (1765-93-1) → 2-amino-5-(p-fluorophenyl)pyridine (503536-73-0)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; ethylene glycol; at 80 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.bmcl.2015.11.018

Reference yield:

5-chloro-2-pyridylamine (1072-98-6) + 4-fluoroboronic acid (1765-93-1) + butan-1-ol (71-36-3) → 2-amino-5-(p-fluorophenyl)pyridine (503536-73-0)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide;

upstream raw materials:

5-bromo-2-pyridylamine

4-fluoroboronic acid

5-chloro-2-pyridylamine

butan-1-ol

Downstream raw materials:

ethyl-[5-(4-fluoro-phenyl)-pyridin-2-yl]-amine

2-amino-3-bromo-5-(4-fluorophenyl)pyridine

Refernces

• 1、 Lakshminarayana, Bhairi,Chakraborty, Jhonti,Satyanarayana,Subrahmanyam, Ch.. "Recyclable Pd/CuFe2O4 nanowires: A highly active catalyst for C-C couplings and synthesis of benzofuran derivatives". . p. 21030 - 21039. Retrieved 2018/06/13.
• 2、 -. "WNT PATHWAY MODULATORS". Paragraph 0251; 0252; 0275; 0276. . Retrieved 2015/07/07.