DL-4-HYDROXYPHENYLLACTIC ACID

Base Information

• Chemical Name: DL-4-HYDROXYPHENYLLACTIC ACID
• CAS No.: 6482-98-0
• Molecular Formula: C₉H₁₀O₄
• Molecular Weight: 182.176
• Mol file: 6482-98-0.mol

Synonyms:alpha,4-Dihydroxybenzenepropanoic acid;3-(p-hydroxyphenyl)-Lactic acid;

Chemical Property of DL-4-HYDROXYPHENYLLACTIC ACID

Chemical Property:

• Boiling Point: 414.4 °C at 760 mmHg
• Flash Point: 218.6 °C
• PSA: 77.76000
• Density: 1.404 g/cm³
• LogP: 0.68430
• Storage Temp.: -20°C Freezer
• Solubility.: Acetone (Very Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

DL-p-Hydroxyphenyllactic acid ≥97% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Total 1 MSDS from other Authors

Useful:

Technology Process of DL-4-HYDROXYPHENYLLACTIC ACID

There total 18 articles about DL-4-HYDROXYPHENYLLACTIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-hydroxyphenylpiruvic acid (156-39-8) → 2-hydroxy-3-(4-hydroxyphenyl)propanoic acid (6482-98-0,23508-35-2,89919-57-3,306-23-0) + ?Tyr (556-02-5,556-03-6,34537-57-0,55520-40-6,96946-98-4,60-18-4,18875-48-4,25619-78-7,30704-25-7)

Guidance literature:

With [Ir(III)Cp*(bpy)(OH₂)](SO₄); ammonium formate; In water; at 80 ℃; for 24h; pH=5.0;

DOI:10.1021/ja031633r

Reference yield: 78.0%

2-hydroxy-3-(4-hydroxyphenyl)acrylic acid (52178-61-7) → 2-hydroxy-3-(4-hydroxyphenyl)propanoic acid (6482-98-0,23508-35-2,89919-57-3,306-23-0)

Guidance literature:

With hydrogenchloride; mercury; zinc; In toluene; at 100 ℃; for 8h;

DOI:10.1055/s-1992-26228

Reference yield: 50.0%

4-hydroxyphenylpiruvic acid (156-39-8) → 2-hydroxy-3-(4-hydroxyphenyl)propanoic acid (6482-98-0,23508-35-2,89919-57-3,306-23-0) + 4-(4-hydroxyphenyl)-5-(4-hydroxyphenylmethyl)-3-hydroxyfurane-2-one (87414-46-8)

Guidance literature:

With hydrogenchloride; amalgamated zinc; Heating;

DOI:10.1016/S0968-0896(02)00446-7

upstream raw materials:

4-hydroxyphenylpiruvic acid

(p-aminophenyl)alanine

2-hydroxy-3-(4-hydroxyphenyl)acrylic acid

methyl 3-(4-hydroxyphenyl)-2-hydroxypropionate

Downstream raw materials:

(S)-2-hydroxy-3-(4-hydroxyphenyl)-N-methoxy-N-methylpropanamide

3-(4-t-butoxycarbonylmethoxyphenyl)-2-(3-chlorobenzyloxy)propionic acid methyl ester

3-(4-carboxymethoxyphenyl)-2-(4-chlorobenzyloxy)propionic acid methyl ester

3-(4-t-butoxycarbonylmethoxyphenyl)-2-(4-chlorobenzyloxy)propionic acid methyl ester

Refernces

• 1、 Ji, Xinjian,Liu, Wan-Qiu,Yuan, Shuguang,Yin, Yue,Ding, Wei,Zhang, Qi. "Mechanistic study of the radical SAM-dependent amine dehydrogenation reactions". . p. 10555 - 10558. Retrieved 2016/09/02.
• 2、 -. "METHOD FOR SYNTHESIS OF KETO ACID OR AMINO ACID BY HYDRATION OF ACETHYLENE COMPOUND". Page/Page column 24. . Retrieved 2008/12/06.