p-Fluorobenzonitrile

Base Information

• Chemical Name: p-Fluorobenzonitrile
• CAS No.: 143234-87-1
• Molecular Formula: C₇H₄FN
• Molecular Weight: 121.114
• Mol file: 143234-87-1.mol

Synonyms:p-Fluorobenzonitrileradical ion(1+)

Chemical Property of p-Fluorobenzonitrile

Chemical Property:

• Boiling Point: 189.6 °C at 760 mmHg
• Flash Point: 65.6 °C
• Density: 1.15 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-Fluorobenzonitrile

There total 189 articles about p-Fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-bromobenzenecarbonitrile (623-00-7) → 4-fluorobenzonitrile (1194-02-1,143234-87-1) + benzonitrile (100-47-0)

Guidance literature:

4-bromobenzenecarbonitrile; With n-butyllithium; In tetrahydrofuran; hexane; at -28 ℃; Flow reactor;

With 2-fluoro-3,3-dimethyl-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide; In tetrahydrofuran; hexane; at -28 ℃; Reagent/catalyst; Flow reactor;

DOI:10.1002/asia.201201191

Reference yield: 58.0%

2,3-di-(p-fluorophenyl)-oxirane (382642-97-9) → 4-fluorobenzonitrile (1194-02-1,143234-87-1) + 4-fluorobenzaldehyde (459-57-4)

Guidance literature:

With sodium azide; copper(II) choride dihydrate; oxygen; In N,N-dimethyl-formamide; at 100 ℃; for 10h; Schlenk technique; Sealed tube;

DOI:10.1039/c5cc00360a

Reference yield: 44.0%

para-fluorobenzylamine (140-75-0) → 4-fluorobenzonitrile (1194-02-1,143234-87-1) + 4-fluorobenzaldehyde (459-57-4)

Guidance literature:

With iodine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 65 ℃; for 1.5h;

DOI:10.1055/s-2008-1067123

upstream raw materials:

(E)-4-fluorobenzaldehyde oxime

acetic anhydride

N,N,N,N,N,N-hexamethylphosphoric triamide

4-Cyanochlorobenzene

Downstream raw materials:

4-(1,1-Dimethyl-dodecyloxy)-benzoic acid

4-(1-Ethyl-1-methyl-pentadecyloxy)-benzoic acid

4-(3-nitrophenoxy)benzonitrile

4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-benzonitrile

Refernces

• 1、 Glaser, Felix,Kerzig, Christoph,Wenger, Oliver S.. "Sensitization-initiated electron transferviaupconversion: mechanism and photocatalytic applications". . p. 9922 - 9933. Retrieved 2021/08/04.
• 2、 Bland, Douglas C.,Lee, So Jeong,Morales-Colón, Mariá T.,Sanford, Melanie S.,Scott, Peter J. H.,See, Yi Yang. "Tetramethylammonium Fluoride Alcohol Adducts for SNAr Fluorination". supporting information. p. 4493 - 4498. Retrieved 2021/06/28.