2,6-Dibromoquinoxaline

Base Information

• Chemical Name: 2,6-Dibromoquinoxaline
• CAS No.: 175858-10-3
• Molecular Formula: C₈H₄Br₂N₂
• Molecular Weight: 287.941
• Hs Code.: 2933990090
• Mol file: 175858-10-3.mol

Synonyms:Quinoxaline, 2,6-dibromo-;

Chemical Property of 2,6-Dibromoquinoxaline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.71
• Boiling Point: 333.707 °C at 760 mmHg
• Flash Point: 155.621 °C
• PSA: 25.78000
• Density: 2.023 g/cm³
• LogP: 3.15480
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2,6-Dibromoquinoxaline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Dibromoquinoxaline

There total 2 articles about 2,6-Dibromoquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

6-bromo-2-hydroxyquinoxaline → 2,6-dibromoquinoxaline (175858-10-3)

Guidance literature:

With phosphorus tribromide; trichlorophosphate; at 170 ℃; for 6h;

DOI:10.1021/ja954173d

Reference yield: 50.0%

6-bromoquinoxalin-2(1H)-one (55687-34-8) → 2,6-dibromoquinoxaline (175858-10-3)

Guidance literature:

With phosphorus(V) oxybromide; at 20 - 130 ℃; Product distribution / selectivity;

Reference yield:

2,6-dibromoquinoxaline (175858-10-3) → 1-(6-Bromoquinoxalin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol (1416805-64-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: bronze powder / dimethyl sulfoxide / 1 h / 20 °C

1.2: 16 h / 20 °C

2.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.08 h / -78 °C

3.1: 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 65 °C / Inert atmosphere

With bronze powder; n-butyllithium; potassium carbonate; In diethyl ether; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

6-bromoquinoxalin-2(1H)-one

Downstream raw materials:

1-(6-Bromoquinoxalin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

C₁₆H₇BrF₄N₂O

C₁₇H₉BrF₄N₂O

Refernces

• 1、 Yamamoto, Takakazu,Sugiyama, Kiyoshi,Kushida, Takashi,Inoue, Tetsuji,Kanbara, Takaki. "Preparation of new electron-accepting π-conjugated polyquinoxalines. Chemical and electrochemical reduction, electrically conducting properties, and use in light-emitting diodes". . p. 3930 - 3937. Retrieved 2007/10/03.