Technology Process of (8R,9R,10S)-9-Benzyloxy-11-(tert-butyl-diphenyl-silanyloxy)-4,6,8,10-tetramethyl-undecane-3,5,7-trione
There total 9 articles about (8R,9R,10S)-9-Benzyloxy-11-(tert-butyl-diphenyl-silanyloxy)-4,6,8,10-tetramethyl-undecane-3,5,7-trione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: p-TsOH / CH2Cl2
2: DIBAL-H / CH2Cl2 / 0 °C
3: 100 percent / pyridine
4: 1.) O3, 2.) Me2S / 1.) CH2Cl2, MeOH
5: NaBH4
6: imidazole
7: 99 percent / K2CO3 / methanol
8: 2.) KMnO4 / 1.) Swern oxid.
9: 1.) (COCl)2, 2.) LDA / 2.) DMPU, -70 deg C
With
pyridine; 1H-imidazole; sodium tetrahydroborate; potassium permanganate; oxalyl dichloride; dimethylsulfide; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; ozone; lithium diisopropyl amide;
In
methanol; dichloromethane;
DOI:10.1016/0040-4039(94)88516-8
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 100 percent / pyridine
2: 1.) O3, 2.) Me2S / 1.) CH2Cl2, MeOH
3: NaBH4
4: imidazole
5: 99 percent / K2CO3 / methanol
6: 2.) KMnO4 / 1.) Swern oxid.
7: 1.) (COCl)2, 2.) LDA / 2.) DMPU, -70 deg C
With
pyridine; 1H-imidazole; sodium tetrahydroborate; potassium permanganate; oxalyl dichloride; dimethylsulfide; potassium carbonate; ozone; lithium diisopropyl amide;
In
methanol;
DOI:10.1016/0040-4039(94)88516-8
- Guidance literature:
-
Multi-step reaction with 8 steps
1: DIBAL-H / CH2Cl2 / 0 °C
2: 100 percent / pyridine
3: 1.) O3, 2.) Me2S / 1.) CH2Cl2, MeOH
4: NaBH4
5: imidazole
6: 99 percent / K2CO3 / methanol
7: 2.) KMnO4 / 1.) Swern oxid.
8: 1.) (COCl)2, 2.) LDA / 2.) DMPU, -70 deg C
With
pyridine; 1H-imidazole; sodium tetrahydroborate; potassium permanganate; oxalyl dichloride; dimethylsulfide; diisobutylaluminium hydride; potassium carbonate; ozone; lithium diisopropyl amide;
In
methanol; dichloromethane;
DOI:10.1016/0040-4039(94)88516-8