C₆₁H₆₂Cl₂N₁₀O₁₇P₂*C₆H₁₅N

Base Information

• Chemical Name: C₆₁H₆₂Cl₂N₁₀O₁₇P₂*C₆H₁₅N
• CAS No.: 94940-28-0
• Molecular Formula: C₆H₁₅N*C₆₁H₆₂Cl₂N₁₀O₁₇P₂
• Molecular Weight: 1441.27
• Mol file: 94940-28-0.mol

Synonyms:

Chemical Property of C₆₁H₆₂Cl₂N₁₀O₁₇P₂*C₆H₁₅N

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₁H₆₂Cl₂N₁₀O₁₇P₂*C₆H₁₅N

There total 10 articles about C₆₁H₆₂Cl₂N₁₀O₁₇P₂*C₆H₁₅N which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine (68892-41-1) → C61H62Cl2N10O17P2*C6H15N (94940-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) N-methylimidazole / 1.) THF, pyridine, 20 deg C, 20 min; 2.) THF, pyridine, 20 deg C, 2 h

2: pyridine; H₂O / 0.25 h / 20 °C

With 1-methyl-1H-imidazole; In pyridine; water;

DOI:10.1002/hlca.19840670521

Reference yield:

C64H65Cl2N11O17P2 (78098-94-9) + triethylamine (121-44-8) → C61H62Cl2N10O17P2*C6H15N (94940-28-0)

Guidance literature:

With water; In pyridine;

DOI:10.1248/cpb.34.2202

Reference yield:

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) (72351-28-1) → C61H62Cl2N10O17P2*C6H15N (94940-28-0)

Guidance literature:

Multi-step reaction with 4 steps

2: H₂O / pyridine

3: mesitylenesulfonyl-3-nitrotriazolide

4: H₂O / pyridine

With mesitylenesulfonyl-3-nitrotriazolide; water; In pyridine;

DOI:10.1248/cpb.34.2202

upstream raw materials:

C₆₄H₆₅Cl₂N₁₁O₁₇P₂

triethylamine

bis(benzotriazol-1-yl)(2-chlorophenyl)phosphate

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

Refernces

• 1、 Chollet, Andre,Ayala, Edgar,Kawashima, Eric H.. "Improved Synthesis of Oligodeoxyribonucleotides by Solid-Phase Phosphotriester Method Utilizing O6--2'-deoxyguanosine Derivatives". . p. 1356 - 1364. Retrieved 2007/10/02.