Benzoyl chloride, 3-iodo-4-Methyl-

Base Information

• Chemical Name: Benzoyl chloride, 3-iodo-4-Methyl-
• CAS No.: 52107-98-9
• Molecular Formula: C8H6 Cl I O
• Molecular Weight: 280.493
• Mol file: 52107-98-9.mol

Synonyms:3-Iodo-4-methylbenzoylchloride

Chemical Property of Benzoyl chloride, 3-iodo-4-Methyl-

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 307.724oC at 760 mmHg
• Flash Point: 139.907oC
• PSA: 17.07000
• Density: 1.819g/cm3
• LogP: 2.97860

Purity/Quality:

98% ^*data from raw suppliers

3-Iodo-4-methylbenzoylchloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoyl chloride, 3-iodo-4-Methyl-

There total 4 articles about Benzoyl chloride, 3-iodo-4-Methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

oxalyl dichloride (79-37-8) → 3-iodo-4-methylbenzoyl chloride (52107-98-9)

Guidance literature:

In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield: 98.0%

3-iodo-4-toluic acid (82998-57-0) → 3-iodo-4-methylbenzoyl chloride (52107-98-9)

Guidance literature:

With thionyl chloride; In chloroform; at 60 ℃; for 16h;

Reference yield:

3-iodo-4-methylbenzonitrile (42872-79-7) → 3-iodo-4-methylbenzoyl chloride (52107-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH

2: SOCl₂

With sodium hydroxide; thionyl chloride;

upstream raw materials:

3-iodo-4-toluic acid

3-iodo-4-methylbenzonitrile

5-cyano-2-methylaniline

oxalyl dichloride

Downstream raw materials:

1,3-dihydro-4-(3-iodo-4-methylbenzoyl)-5-methyl-2H-1,3-imidazol-2-one

3-iodo-4-methyl-benzoic acid amide

3-iodo-4-methylbenzaldehyde

N-(2,3-dihydro-1H-inden-4-yl)-3-iodo-4-methylbenzamide

Refernces

• 1、 Zhang, Dongfeng,Li, Peng,Gao, Yongxin,Song, Yaoyao,Zhu, Yaqin,Su, Hong,Yang, Beibei,Li, Li,Li, Gang,Gong, Ningbo,Lu, Yang,Shao, Huanjie,Yu, Chunrong,Huang, Haihong. "Discovery of a Candidate Containing an (S)-3,3-Difluoro-1-(4-methylpiperazin-1-yl)-2,3-dihydro-1 H-inden Scaffold as a Highly Potent Pan-Inhibitor of the BCR-ABL Kinase including the T315I-Resistant Mutant for the Treatment of Chronic Myeloid Leukemia". . p. 7434 - 7452. Retrieved 2021/06/25.
• 2、 -. "COMPOUNDS USEFUL FOR INHIBITING RAF DIMERS". Paragraph 0151; 0152. . Retrieved 2020/09/12.