6-Bromo-2-methyl-[1,2,4]triazolo[1,5-a]pyridine

Base Information

• Chemical Name: 6-Bromo-2-methyl-[1,2,4]triazolo[1,5-a]pyridine
• CAS No.: 7169-95-1
• Molecular Formula: C7H6 Br N3
• Molecular Weight: 212.049
• Hs Code.: 2933990090
• European Community (EC) Number: 865-006-5
• DSSTox Substance ID: DTXSID70346321
• Nikkaji Number: J1.415.509K
• Wikidata: Q72448204
• Mol file: 7169-95-1.mol

Synonyms:6-bromo-2-methyl-[1,2,4]triazolo[1,5-a]pyridine;7169-95-1;6-Bromo-2-methyl[1,2,4]triazolo[1,5-a]pyridine;6-Bromo-2-methyl-1,2,4-triazolo(2,3-a)pyridine;SCHEMBL618586;DTXSID70346321;BCP19243;CS-B0790;MFCD09038167;AKOS015919821;AB49513;DS-1730;FS-3322;AC-30789;AM804270;FT-0698889;EN300-112235;A866390;2-Methyl-6-bromo[1,2,4]triazolo[1,5-a]pyridine;6-Bromo-2-methyl[1,2,4]triazolo[1,5-a]pyridine #;Z1070115892

Chemical Property of 6-Bromo-2-methyl-[1,2,4]triazolo[1,5-a]pyridine

Chemical Property:

• Melting Point: 153-155℃
• PKA: 2.23±0.30(Predicted)
• PSA: 30.19000
• Density: 1.76±0.1 g/cm3(Predicted)
• LogP: 1.80020
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 210.97451
• Heavy Atom Count: 11
• Complexity: 153

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-2-methyl-[1,2,4]triazolo[1,5-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NN2C=C(C=CC2=N1)Br

Technology Process of 6-Bromo-2-methyl-[1,2,4]triazolo[1,5-a]pyridine

There total 6 articles about 6-Bromo-2-methyl-[1,2,4]triazolo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(1,2-diamino-5-bromopyridin-1-ium) 2,4,6-trimethylbenzenesulfonate (1202704-57-1) + acetic anhydride (108-24-7) → 6-bromo-2-methyl-[1,2,4]triazolo[1,5-a]pyridine (7169-95-1)

Guidance literature:

(1,2-diamino-5-bromopyridin-1-ium) 2,4,6-trimethylbenzenesulfonate; acetic anhydride; With hydrogenchloride; In water; for 14h; Reflux;

With sodium hydrogencarbonate; In water;

Reference yield: 12.0%

(1,2-diamino-5-bromopyridin-1-ium) 2,4,6-trimethylbenzenesulfonate + acetic anhydride (108-24-7) → 6-bromo-2-methyl-[1,2,4]triazolo[1,5-a]pyridine (7169-95-1)

Guidance literature:

(1,2-diamino-5-bromopyridin-1-ium) 2,4,6-trimethylbenzenesulfonate; acetic anhydride; With toluene-4-sulfonic acid; at 110 ℃; for 24h; Sealed tube;

With triethyloxonium fluoroborate; In dichloromethane; at 20 ℃;

Reference yield: 12.0%

(1,2-diamino-5-bromopyridin-1-ium) 2,4,6-trimethylbenzenesulfonate (1202704-57-1) + triethyloxonium fluoroborate (368-39-8) → 6-bromo-2-methyl-[1,2,4]triazolo[1,5-a]pyridine (7169-95-1)

Guidance literature:

(1,2-diamino-5-bromopyridin-1-ium) 2,4,6-trimethylbenzenesulfonate; With p-toluenesulfonic acid monohydrate; In acetic anhydride; at 100 ℃; for 24h;

triethyloxonium fluoroborate; In dichloromethane; at 20 ℃;

upstream raw materials:

5-bromo-2-pyridylamine

(1,2-diamino-5-bromopyridin-1-ium) 2,4,6-trimethylbenzenesulfonate

acetic anhydride

triethyloxonium fluoroborate

Downstream raw materials:

(S)-6-(2-hydroxy-2-methylpropyl)-6-isopropyl-3-((S)-1-(4-(2-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)ethyl)-1,3-oxazinan-2-one

C₁₉H₁₈FN₅O₃

2-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-amine

Refernces

• 1、 -. "Substituted heteroaryl compounds and compositions and uses thereof (by machine translation)". Paragraph 1104; 1113; 1114; 1115. . Retrieved 2019/06/07.
• 2、 -. "CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1". Page/Page column 72. . Retrieved 2010/08/18.