2-BROMO-4-CYANOTHIAZOLE

Base Information

• Chemical Name: 2-BROMO-4-CYANOTHIAZOLE
• CAS No.: 848501-90-6
• Molecular Formula: C4HBrN2S
• Molecular Weight: 189.035
• Hs Code.: 2934100090
• Mol file: 848501-90-6.mol

Synonyms:2-Bromo-1,3-thiazole-4-carbonitrile;2-Bromo-4-cyanothiazole;

Chemical Property of 2-BROMO-4-CYANOTHIAZOLE

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.651
• Boiling Point: 276.099 °C at 760 mmHg
• PKA: -3.33±0.10(Predicted)
• Flash Point: 120.78 °C
• PSA: 64.92000
• Density: 1.972 g/cm³
• LogP: 1.77728
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-4-cyanothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-4-CYANOTHIAZOLE

There total 1 articles about 2-BROMO-4-CYANOTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-bromo-1,3-thiazole-4-carboxamide (848501-94-0) → 2-bromothiazole-4-carbonitrile (848501-90-6)

Guidance literature:

at 325 ℃; for 1h; Temperature;

Reference yield: 49.0%

2-bromothiazole-4-carbonitrile (848501-90-6) + 2-hydroxyphenyl boronic acid (89466-08-0) → 2-(2-hydroxyphenyl)thiazole-4-carbonitrile

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 20 - 150 ℃; for 0.833333h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.biochem.6b00735

Reference yield: 42.0%

2-bromothiazole-4-carbonitrile (848501-90-6) + (5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)(piperazin-1-yl)methanone → 2-(4-(5-phenyl-4,5-dihydro-1H-pyrazole-1-carbonyl)piperazin-1-yl)thiazole-4-carbonitrile

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 140 ℃; for 8h; Inert atmosphere;

upstream raw materials:

2-bromo-1,3-thiazole-4-carboxamide

Refernces

• 1、 -. "NUCLEAR TRANSPORT MODULATIORS AND USES THEREOF". Page/Page column 225. . Retrieved 2011/10/03.