C₂₁H₂₈N₄O₄

Base Information

• Chemical Name: C₂₁H₂₈N₄O₄
• CAS No.: 1421257-26-2
• Molecular Formula: C₂₁H₂₈N₄O₄
• Molecular Weight: 400.478
• Mol file: 1421257-26-2.mol

Synonyms:

Chemical Property of C₂₁H₂₈N₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₈N₄O₄

There total 4 articles about C₂₁H₂₈N₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(1S,3S)-3-aminocyclohexyl]methanol (1202411-97-9) + C14H15N3O4 → C21H28N4O4 (1421257-26-2)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2012.11.109

Reference yield:

C16H19N3O4 → C21H28N4O4 (1421257-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: water; sodium hydroxide / methanol / 8 h / 20 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.11.109

Reference yield:

2-Aminophenol-4-carboxylic acid amide (120629-58-5) → C21H28N4O4 (1421257-26-2)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium hydroxide / ethanol / 16 h / Reflux

2: toluene / 16 h / Reflux

3: water; sodium hydroxide / methanol / 8 h / 20 °C

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; potassium hydroxide; sodium hydroxide; In methanol; ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2012.11.109

upstream raw materials:

2-Aminophenol-4-carboxylic acid amide

[(1S,3S)-3-aminocyclohexyl]methanol

Refernces