Technology Process of (R)-2-((Z)-(R)-3-Carboxy-1-methyl-but-2-enyl)-7-chloro-4,6-dimethoxy-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester
There total 1 articles about (R)-2-((Z)-(R)-3-Carboxy-1-methyl-but-2-enyl)-7-chloro-4,6-dimethoxy-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 9 steps
1: 93 percent / pyridine
2: 94 percent / AlCl3 / chlorobenzene / 0.5 h / Heating
3: 73 percent / diisopropylazodicarboxylate, tributylphosphine
4: 78 percent / LHMDS / tetrahydrofuran / -78 °C
5: 95 percent / MsN3, Et3N
6: 62 percent / 5 mol percent of rhodium pivalate 2(piv)4> / benzene / 1 h / Heating
7: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH
8: tetrahydrofuran / Ambient temperature
9: 100 percent / TFA
With
pyridine; aluminium trichloride; rhodium(II) pivalate; 2,3-dimercapto-succinic acid; tributylphosphine; di-isopropyl azodicarboxylate; ozone; triethylamine; Methanesulfonyl azide; trifluoroacetic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; chlorobenzene; benzene;
DOI:10.1021/ja00022a075
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h
2: 49 percent / NaOMe / methanol / Ambient temperature
3: 95 percent / tetrahydrofuran / Ambient temperature
With
hydrogenchloride; diphenyl phosphoryl azide; sodium methylate; triethylamine;
In
tetrahydrofuran; methanol;
DOI:10.1021/ja00022a075