Technology Process of C25H29Cl2NO3
There total 10 articles about C25H29Cl2NO3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)piperidin-2-one;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
for 0.333333h;
Inert atmosphere;
tert-butyl 2-bromobutyrate;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 25 ℃;
for 24h;
optical yield given as %de;
Inert atmosphere;
DOI:10.1021/jm300354j
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium azide / N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere
2.1: trimethylphosphane / tetrahydrofuran; water / 1 h / 25 °C / Inert atmosphere
3.1: sodium hydrogencarbonate / methanol; water / Inert atmosphere; Reflux
4.1: Chiralcel OD-H / hexane; isopropyl alcohol / Resolution of racemate
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere
5.2: 24 h / 0 - 25 °C / Inert atmosphere
With
sodium azide; sodium hydride; sodium hydrogencarbonate; trimethylphosphane;
In
tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;
DOI:10.1021/jm300354j
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trimethylphosphane / tetrahydrofuran; water / 1 h / 25 °C / Inert atmosphere
2.1: sodium hydrogencarbonate / methanol; water / Inert atmosphere; Reflux
3.1: Chiralcel OD-H / hexane; isopropyl alcohol / Resolution of racemate
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere
4.2: 24 h / 0 - 25 °C / Inert atmosphere
With
sodium hydride; sodium hydrogencarbonate; trimethylphosphane;
In
tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;
DOI:10.1021/jm300354j