(S)-2-Acetamido-N-benzyl-3-methoxypropanamide

Base Information Edit

Chemical Name:(S)-2-Acetamido-N-benzyl-3-methoxypropanamide
CAS No.:175481-37-5
Molecular Formula:C₁₃H₁₈N₂O₃
Molecular Weight:250.298
Hs Code.:2924296000
UNII:3F3M716PY8
DSSTox Substance ID:DTXSID00442825
Nikkaji Number:J2.881.523I
Wikidata:Q27457556
ChEMBL ID:CHEMBL58322
Mol file:175481-37-5.mol

Synonyms:175481-37-5;(S)-2-ACETAMIDO-N-BENZYL-3-METHOXYPROPANAMIDE;(S)-Lacosamide;N~2~-Acetyl-N-Benzyl-O-Methyl-L-Serinamide;Lacosamide, (S)-;(2S)-2-acetamido-N-benzyl-3-methoxypropanamide;3F3M716PY8;SPM-6953;(2S)-2-(Acetylamino)-3-methoxy-N-(phenylmethyl)propanamide;3ieo;CHEMBL58322;SCHEMBL225889;UNII-3F3M716PY8;DTXSID00442825;AKOS022172913;LACOSAMIDE S-ENANTIOMER [USP-RS];AC-25782;LACOSAMIDE IMPURITY A [EP IMPURITY];(s)-N-benzyl 2-acetamido-3-methoxypropionamide;Q27457556;PROPANAMIDE, 2-(ACETYLAMINO)-3-METHOXY-N-(PHENYLMETHYL)-, (2S)-;AMJ

Suppliers and Price of (S)-2-Acetamido-N-benzyl-3-methoxypropanamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Epi-Lacosamide
25mg
$ 410.00

AK Scientific
(S)-2-Acetamido-N-benzyl-3-methoxypropanamide
1g
$ 1680.00

Total 30 raw suppliers

Chemical Property of (S)-2-Acetamido-N-benzyl-3-methoxypropanamide Edit

Chemical Property:

Vapor Pressure:0Pa at 25℃
Boiling Point:536.447 °C at 760 mmHg
PKA:14.19±0.46(Predicted)
Flash Point:278.233 °C
PSA：74.41000
Density:1.12 g/cm³
LogP:2.13450
XLogP3:0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:250.13174244
Heavy Atom Count:18
Complexity:275

Purity/Quality:

98% ^*data from raw suppliers

Epi-Lacosamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC(COC)C(=O)NCC1=CC=CC=C1
Isomeric SMILES:CC(=O)N[C@@H](COC)C(=O)NCC1=CC=CC=C1
Recent EU Clinical Trials:A MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL TO ASSESS THE EFFICACY AND SAFETY OF 400MG/DAY LACOSAMIDE IN SUBJECTS WITH PAINFUL DISTAL DIABETIC NEUROPATHY USING TWO DIFFERENT TITRATION SCHEMES
Uses Epi-Lacosamide is an impurity of Lacosamide, a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.

Technology Process of (S)-2-Acetamido-N-benzyl-3-methoxypropanamide

There total 140 articles about (S)-2-Acetamido-N-benzyl-3-methoxypropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

: 1346680-39-4
(Z)-2-acetamido-N-benzyl-3-methoxyacrylamide

: 175481-36-4,175481-37-5
lacosamide

Guidance literature:: With hydrogen; (-)-1,2-bis((2S,5S)-2,5-diphenylphospholano)ethane(1,5-cyclooctadiene)rhodium (I) tetrafluoroborate; In methanol; at 45 ℃; for 20h; under 7500.75 Torr; Inert atmosphere; Sealed vessel;

Reference yield: 94.0%

: 1084734-55-3
N-acetyl-β-methoxy-D-alanine ethyl ester

: 100-46-9
benzylamine

: 175481-36-4,175481-37-5
lacosamide

Guidance literature:: benzylamine; With trimethylaluminum; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

N-acetyl-β-methoxy-D-alanine ethyl ester; In dichloromethane; for 3h; Inert atmosphere;
DOI:10.1055/s-0036-1588093