Technology Process of (R)-3-(2,3-dihydroxypropyl)-5-(4-ethynyl-2-fluorophenylamino)-6-fluoro-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
There total 12 articles about (R)-3-(2,3-dihydroxypropyl)-5-(4-ethynyl-2-fluorophenylamino)-6-fluoro-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: potassium carbonate / ethanol
2: 1-methyl-pyrrolidin-2-one; diphenylether / 240 °C
3: trichlorophosphate
4: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane
5: acetic acid; zinc
6: hydrogenchloride; potassium iodide; sodium nitrite
7: ammonium formate; palladium(II) hydroxide / 1,4-dioxane
8: potassium carbonate / N,N-dimethyl-formamide
9: Selectfluor / acetonitrile
11: tetrabutyl ammonium fluoride
With
hydrogenchloride; tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride; ammonium formate; palladium(II) hydroxide; potassium carbonate; acetic acid; Selectfluor; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium iodide; sodium t-butanolate; zinc; sodium nitrite; trichlorophosphate;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; diphenylether; ethanol; N,N-dimethyl-formamide; acetonitrile;
10: Sonogashira coupling;
DOI:10.1016/j.bmcl.2011.01.071
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Selectfluor / acetonitrile
3: tetrabutyl ammonium fluoride
With
tetrabutyl ammonium fluoride; Selectfluor;
In
acetonitrile;
2: Sonogashira coupling;
DOI:10.1016/j.bmcl.2011.01.071
- Guidance literature:
-
Multi-step reaction with 9 steps
1: trichlorophosphate
2: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane
3: acetic acid; zinc
4: hydrogenchloride; potassium iodide; sodium nitrite
5: ammonium formate; palladium(II) hydroxide / 1,4-dioxane
6: potassium carbonate / N,N-dimethyl-formamide
7: Selectfluor / acetonitrile
9: tetrabutyl ammonium fluoride
With
hydrogenchloride; tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride; ammonium formate; palladium(II) hydroxide; potassium carbonate; acetic acid; Selectfluor; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium iodide; sodium t-butanolate; zinc; sodium nitrite; trichlorophosphate;
In
1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;
8: Sonogashira coupling;
DOI:10.1016/j.bmcl.2011.01.071