Benzoicacid, 2-amino-5-(3-thienyl)-

Base Information

• Chemical Name: Benzoicacid, 2-amino-5-(3-thienyl)-
• CAS No.: 885268-34-8
• Molecular Formula: C₁₁H₉NO₂S
• Molecular Weight: 219.264
• Mol file: 885268-34-8.mol

Synonyms:

Chemical Property of Benzoicacid, 2-amino-5-(3-thienyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoicacid, 2-amino-5-(3-thienyl)-

There total 2 articles about Benzoicacid, 2-amino-5-(3-thienyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-carbomethoxyaniline (134-20-3) → C11H9NO2S (885268-34-8)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrahydrofuran / 72 h / Reflux

2: bromine; sodium acetate; acetic acid / 14 h

3: tetrabutylammomium bromide; palladium diacetate; sodium carbonate / water / 0.17 h / 200 °C

4: lithium hydroxide / tetrahydrofuran / 20 °C

5: trifluoroacetic acid / dichloromethane

With tetrabutylammomium bromide; bromine; sodium acetate; palladium diacetate; sodium carbonate; acetic acid; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; 3: Suzuki-Miyaura cross-coupling;

DOI:10.1002/cbic.201200228

Reference yield:

methyl 2-((tert-butoxycarbonyl)amino)benzoate → C11H9NO2S (885268-34-8)

Guidance literature:

Multi-step reaction with 4 steps

1: bromine; sodium acetate; acetic acid / 14 h

2: tetrabutylammomium bromide; palladium diacetate; sodium carbonate / water / 0.17 h / 200 °C

3: lithium hydroxide / tetrahydrofuran / 20 °C

4: trifluoroacetic acid / dichloromethane

With tetrabutylammomium bromide; bromine; sodium acetate; palladium diacetate; sodium carbonate; acetic acid; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; 2: Suzuki-Miyaura cross-coupling;

DOI:10.1002/cbic.201200228

upstream raw materials:

2-carbomethoxyaniline

Refernces