N-(4-FLUOROPHENYL)-3-CHLOROPROPANAMIDE

Base Information

• Chemical Name: N-(4-FLUOROPHENYL)-3-CHLOROPROPANAMIDE
• CAS No.: 56767-37-4
• Molecular Formula: C₉H₉ClFNO
• Molecular Weight: 201.628
• Hs Code.: 2924299090
• Mol file: 56767-37-4.mol

Synonyms:3-Chloro-4'-fluoropropionanilide

Chemical Property of N-(4-FLUOROPHENYL)-3-CHLOROPROPANAMIDE

Chemical Property:

• Melting Point: 120-122°C
• PSA: 29.10000
• LogP: 2.46610

Purity/Quality:

98%Min ^*data from raw suppliers

3-Chloro-N-(4-fluorophenyl)propanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3-chloro-N-(4-fluorophenyl)propanamide is a useful reactant for the synthesis of 5,?5-?diphenylimidazolidine-?2,?4-?dione derivatives which have been studied for its anti-?inflammatory, and analgesic activities.

Technology Process of N-(4-FLUOROPHENYL)-3-CHLOROPROPANAMIDE

There total 1 articles about N-(4-FLUOROPHENYL)-3-CHLOROPROPANAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloropropionyl chloride (625-36-5) + 4-fluoroaniline (371-40-4) → 3-chloro-N-(4-fluorophenyl)propionamide (56767-37-4)

Guidance literature:

4-fluoroaniline; With sodium acetate; acetic acid; In water; at 5 ℃;

2-chloropropionyl chloride; at 0 - 20 ℃;

upstream raw materials:

2-chloropropionyl chloride

4-fluoroaniline

Refernces

• 1、 -. "Compound for inhibiting EGFR kinase as well as preparation method and application thereof". Paragraph 0040; 0071-0073. . Retrieved 2021/01/12.
• 2、 Niso, Mauro,Pati, Maria Laura,Berardi, Francesco,Abate, Carmen. "Rigid: Versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracers". . p. 88508 - 88518. Retrieved 2016/09/28.