4-sulfamoylbenzenesulfonyl Chloride

Base Information

• Chemical Name: 4-sulfamoylbenzenesulfonyl Chloride
• CAS No.: 46249-41-6
• Molecular Formula: C6H6ClNO4S2
• Molecular Weight: 255.703
• Hs Code.: 2935009090
• European Community (EC) Number: 816-065-0
• DSSTox Substance ID: DTXSID10449764
• Mol file: 46249-41-6.mol

Synonyms:46249-41-6;4-(aminosulfonyl)benzenesulfonyl chloride;4-sulfamoylbenzenesulfonyl Chloride;4-Sulfamoylbenzene-1-sulfonyl chloride;Benzenesulfonyl chloride, 4-(aminosulfonyl)-;Benzenesulfonylchloride, 4-(aminosulfonyl)-;4-sulfamoylbenzenesulphonyl chloride;SCHEMBL2367293;DTXSID10449764;MFCD07352256;4-Sulfamoylbenzene-1-sulfonylchloride;AKOS000118393;BS-13915;Benzenesulfonylchloride,4-(aminosulfonyl)-;CS-0072200;EN300-14899;E80973;A904221;4-(aminosulfonyl)benzenesulfonyl chloride, AldrichCPR;F3351-0215;Z108576592

Chemical Property of 4-sulfamoylbenzenesulfonyl Chloride

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.597
• Boiling Point: 433.957 °C at 760 mmHg
• Flash Point: 216.25 °C
• PSA: 111.06000
• Density: 1.649 g/cm³
• LogP: 3.12340
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 254.9426777
• Heavy Atom Count: 14
• Complexity: 383

Purity/Quality:

99% ^*data from raw suppliers

4-(Aminosulfonyl)benzenesulfonyl chloride 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1S(=O)(=O)N)S(=O)(=O)Cl

Technology Process of 4-sulfamoylbenzenesulfonyl Chloride

There total 5 articles about 4-sulfamoylbenzenesulfonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

sulfanilamide (63-74-1) → 4-sulfamoylbenzene-1-sulfonyl chloride (46249-41-6)

Guidance literature:

sulfanilamide; With hydrogenchloride; sodium nitrite; In water; Cooling with ice;

With sulfur dioxide; acetic acid; copper dichloride; In water; for 0.166667h;

Reference yield:

sulfanilamide (63-74-1) + sodium nitrite (7632-00-0) → 4-sulfamoylbenzene-1-sulfonyl chloride (46249-41-6)

Guidance literature:

With hydrogenchloride; acetic acid; copper(I) chloride; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water; ethyl acetate; toluene;

Reference yield:

cupric chloride·dihydrate + sulfanilamide (63-74-1) → 4-sulfamoylbenzene-1-sulfonyl chloride (46249-41-6)

Guidance literature:

With concentrated hydrochloric acid; acetic acid; sodium nitrite; In tetrahydrofuran; water;

upstream raw materials:

4-(aminosulphonyl)benzenediazonium chloride

sulfanilamide

sodium nitrite

Downstream raw materials:

benzene-1,4-disulfonamide

p-(2,3-Dihydroxypropylsulfamoyl)benzolsulfonamid

N-(3-morpholinopropyl)benzene-1,4-disulfonamide

C₁₉H₂₄N₄O₉S₄

Refernces

• 1、 -. "Benzenesulfonamide derivatives and pharmaceutical composition thereof". Page/Page column 14-15. . Retrieved 2011/10/10.
• 2、 -. "SUBSITUTED SULPHONAMIDES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION COMPRISING THEREOF AND THEIR USE". Page/Page column 7; 11-12. . Retrieved 2008/12/08.