2-(2-Methyl-5-nitrophenyl)aceticacid

Base Information

• Chemical Name: 2-(2-Methyl-5-nitrophenyl)aceticacid
• CAS No.: 287119-83-9
• Molecular Formula: C9H9NO4
• Molecular Weight: 195.175
• Hs Code.: 2916399090
• Mol file: 287119-83-9.mol

Synonyms:2-Methyl-5-nitrophenylaceticacid;

Chemical Property of 2-(2-Methyl-5-nitrophenyl)aceticacid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.587
• Boiling Point: 400.385 °C at 760 mmHg
• Flash Point: 178.807 °C
• PSA: 83.12000
• Density: 1.346 g/cm³
• LogP: 2.05350
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Methyl-5-nitrophenyl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Methyl-5-nitrophenyl)aceticacid

There total 7 articles about 2-(2-Methyl-5-nitrophenyl)aceticacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

→ 2-(2-Methyl-5-nitrophenyl)acetic acid (287119-83-9)

Guidance literature:

Reference yield: 42.0%

o-methylphenylacetic acid (644-36-0) → 2-(2-Methyl-5-nitrophenyl)acetic acid (287119-83-9)

Guidance literature:

With sulfuric acid; nitric acid; In dichloromethane; at -20 - 20 ℃;

Reference yield:

2-(2-methyl-5-nitrophenyl)acetonitrile (409082-11-7) → 2-(2-Methyl-5-nitrophenyl)acetic acid (287119-83-9)

Guidance literature:

With methanol; potassium hydroxide; water; for 14h; Heating / reflux;

upstream raw materials:

o-methylphenylacetic acid

2-(2-methyl-5-nitrophenyl)acetonitrile

(2-methyl-5-nitrophenyl)-methyl methylsulfonate

(2-methyl-5-nitro-7-phenyl)methanol

Downstream raw materials:

2-methyl-5-nitrophenylacetic acid methyl ester

2-(2-methanesulfonyloxyethyl)-1-methyl-4-nitrobenzene

N-(4-methyl-3-{1-methyl-7-[3-(4-methyl-piperazin-1-y)-phenylamino]-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl}-phenyl)-3-trifluoromethyl-benzamide

N-{3-[7-(3-dimethylaminomethyl-phenylamino)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl]-4-methyl-phenyl}-3-trifluoromethyl-benzamide

Refernces

• 1、 -. "RORGAMMA MODULATORS AND USES THEREOF". Page/Page column 38. . Retrieved 2018/09/02.
• 2、 -. "4-Saturated cyclosubstituted aniline protein kinase inhibitor". Paragraph 0099; 0101; 0102; 0103. . Retrieved 2017/04/29.