1-CHLORO-4-(4-FLUOROPHENYL)PHTHALAZINE

Base Information

• Chemical Name: 1-CHLORO-4-(4-FLUOROPHENYL)PHTHALAZINE
• CAS No.: 155937-28-3
• Molecular Formula: C14H8ClFN2
• Molecular Weight: 258.682
• Hs Code.: 2933990090
• Mol file: 155937-28-3.mol

Synonyms:Phthalazine, 1-chloro-4-(4-fluorophenyl)-;

Chemical Property of 1-CHLORO-4-(4-FLUOROPHENYL)PHTHALAZINE

Chemical Property:

• Melting Point: 196-197℃
• Boiling Point: 440.8 °C at 760 mmHg
• Flash Point: 220.4 °C
• PSA: 25.78000
• Density: 1.351 g/cm³
• LogP: 4.08930

Purity/Quality:

99% ^*data from raw suppliers

1-Chloro-4-(4-fluorophenyl)phthalazine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-CHLORO-4-(4-FLUOROPHENYL)PHTHALAZINE

There total 1 articles about 1-CHLORO-4-(4-FLUOROPHENYL)PHTHALAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-(4-fluoro-phenyl)-2H-phthalazin-1-one (1766-63-8) → 1-chloro-4-(4-fluorophenyl)-1-phthalazine (155937-28-3)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 1.5h;

DOI:10.1016/0223-5234(94)90205-4

Reference yield: 96.0%

1-chloro-4-(4-fluorophenyl)-1-phthalazine (155937-28-3) + (S)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester (169447-70-5) → (S)-tert-butyl 4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methylpiperazine-1-carboxylate (1228022-16-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 25 - 102 ℃; for 57h; Product distribution / selectivity;

Reference yield: 95.0%

1-chloro-4-(4-fluorophenyl)-1-phthalazine (155937-28-3) + tert-butyl methyl(piperidin-4-yl)carbamate (108612-54-0) → {1-[4-(4-fluoro-phenyl)phthalazin-1-yl]-piperidin-4-yl}-methyl-carbamic acid tert-butyl ester (1192268-00-0)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 110 ℃; for 3h; Product distribution / selectivity;

upstream raw materials:

4-(4-fluoro-phenyl)-2H-phthalazin-1-one

Downstream raw materials:

1-(4-Fluoro-phenyl)-4-phenoxy-phthalazine

4-(4-Fluoro-phenyl)-phthalazin-1-ylamine

{1-[4-(4-fluoro-phenyl)phthalazin-1-yl]-piperidin-4-yl}-methyl-carbamic acid tert-butyl ester

(S)-1-(4-fluorophenyl)-4-(3-methylpiperazin-1-yl)phthalazine

Refernces