7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE

Base Information

• Chemical Name: 7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE
• CAS No.: 62458-96-2
• Molecular Formula: C14H15N3O
• Molecular Weight: 241.293
• Hs Code.: 2933990090
• Mol file: 62458-96-2.mol

Synonyms:Pyrido[3,4-d]pyrimidin-4(1H)-one,5,6,7,8-tetrahydro-7-(phenylmethyl)- (9CI);7-Benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one;7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one;

Chemical Property of 7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 2.61E-07mmHg at 25°C
• Melting Point: 198 °C
• Refractive Index: 1.662
• Boiling Point: 410.1 °C at 760 mmHg
• PKA: 7.77±0.20(Predicted)
• Flash Point: 201.8 °C
• PSA: 48.99000
• Density: 1.27 g/cm³
• LogP: 2.06810
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE

There total 9 articles about 7-BENZYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

formamidine acetic acid (3473-63-0) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one (62458-96-2)

Guidance literature:

With sodium methylate; In methanol; for 2h; Heating / reflux;

Reference yield: 79.0%

formamidine acetic acid (3473-63-0) + ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride (52763-21-0) → 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one (62458-96-2)

Guidance literature:

With sodium methylate; In methanol; at 25 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.bmcl.2015.11.009

Reference yield:

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride (52763-21-0) → 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-ol (62458-96-2)

Guidance literature:

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride; With sodium methylate; formamidine; In methanol; at 20 ℃;

With acetic acid; In methanol;

upstream raw materials:

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate

formamidine

formamidine acetic acid

Downstream raw materials:

7-Benzyl-4-chloro-5,6,7,8-tetrahydro-1,3,7-triazanaphthalene

C₇H₉N₃O

4-hydroxy-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester

4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "ANTI-ANGIOGENESIS COMPOUND, INTERMEDIATE AND USE THEREOF". . . Retrieved 2016/04/10.
• 2、 -. "ANTI-ANGIOGENESIS COMPOUND, INTERMEDIATE AND USE THEREOF". . . Retrieved 2016/11/02.