2,4,6-Tribromopyridine

Base Information

• Chemical Name: 2,4,6-Tribromopyridine
• CAS No.: 2408-70-0
• Molecular Formula: C5H2 Br3 N
• Molecular Weight: 315.79
• Hs Code.: 2933399090
• European Community (EC) Number: 835-090-8
• DSSTox Substance ID: DTXSID20542210
• Wikidata: Q72509936
• Mol file: 2408-70-0.mol

Synonyms:2,4,6-TRIBROMOPYRIDINE;2408-70-0;MFCD00234002;Pyridine, 2,4,6-tribromo-;2,4,6-Tribrom-pyridin;SCHEMBL724151;DTXSID20542210;WALXYTCBNHJWER-UHFFFAOYSA-N;BISMUTH(III)NITRATEPENTAHYDRATE;AKOS005067835;AM84818;CS-W006226;DS-1502;SY010212;T3375;EN300-176714;A878023;W-206873

Chemical Property of 2,4,6-Tribromopyridine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 105-106oC
• Boiling Point: 306.152oC at 760 mmHg
• PKA: -3.01±0.10(Predicted)
• Flash Point: 138.956oC
• PSA: 12.89000
• Density: 2.407g/cm3
• LogP: 3.36910
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 314.77169
• Heavy Atom Count: 9
• Complexity: 88.2

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4,6-Tribromopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(N=C1Br)Br)Br

Technology Process of 2,4,6-Tribromopyridine

There total 10 articles about 2,4,6-Tribromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.7%

2,6-dibromo-4-nitro-pyridine 1-oxide (98027-81-7) + Acetyl bromide (506-96-7) → 2,4,6-tribromopyridine (2408-70-0)

Guidance literature:

2,6-dibromo-4-nitro-pyridine 1-oxide; Acetyl bromide; With acetic acid; at 60 - 80 ℃; for 2.5h; Inert atmosphere;

With phosphorus tribromide; In chloroform; at 20 - 65 ℃; for 25h; Inert atmosphere;

DOI:10.1016/j.dyepig.2012.11.014

Reference yield:

2,6-Dibromopyridine (626-05-1) + bromine (7726-95-6) → 2,4,6-tribromopyridine (2408-70-0) + 2,3,4,6-tetrabromo-pyridine (101252-31-7) + pentabromopyridine (2402-94-0)

Guidance literature:

at 500 - 530 ℃; Leiten ueber Bimsstein;

Reference yield:

2,6-Dibromopyridine (626-05-1) → 2,4,6-tribromopyridine (2408-70-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / 35percent H₂O₂ / trifluoroacetic acid / 3 h / 80 °C

2: 85 percent / oleum, HNO₃ / 2 h / 90 °C

3: 1.) acetyl bromide; 2.) PBr₃ / 1.) glacial acetic acid, 2 h, 80 deg C; 2.) CHCl₃, 1 h, RT; 2 d, reflux

With Acetyl bromide; sulfuric acid; dihydrogen peroxide; nitric acid; phosphorus tribromide; In trifluoroacetic acid;

upstream raw materials:

3-Amino-2,4,6-tribromopyridine

2,6-dibromo-4-nitro-pyridine 1-oxide

2,6-Dibromopyridine

bromine

Downstream raw materials:

2,4,6-trimethoxypyridine

2,6-dibromo-4-phenoxypyridine

4-amino-2,6-dibromopyridine

2-amino-4,6-dibromopyridine

Refernces

• 1、 Neumann, Uwe,Voegtle, Fritz. "4,4'-Donor-Substituted and 6,6'-Difunctionalized 2,2'-Bipyridines". . p. 589 - 592. Retrieved 2007/10/02.