4-METHYLPHENYLGLYOXAL HYDRATE

Base Information

• Chemical Name: 4-METHYLPHENYLGLYOXAL HYDRATE
• CAS No.: 1075-47-4
• Molecular Formula: C9H8 O2
• Molecular Weight: 148.161
• Hs Code.: 2912190090
• Mol file: 1075-47-4.mol

Synonyms:Glyoxal,p-tolyl- (7CI,8CI); (4-Tolyl)ethanedial; 4-Methylphenylglyoxal; 4-Tolylglyoxal;p-Methylphenylglyoxal; p-Tolylglyoxal

Chemical Property of 4-METHYLPHENYLGLYOXAL HYDRATE

Chemical Property:

• Vapor Pressure: 0.000109mmHg at 25°C
• Melting Point: 104-161 °C
• Boiling Point: 323.2oC at 760 mmHg
• Flash Point: 149.3oC
• PSA: 43.37000
• Density: 1.101±0.06 g/cm3(Predicted)
• LogP: 1.31230

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYLPHENYLGLYOXAL HYDRATE

There total 14 articles about 4-METHYLPHENYLGLYOXAL HYDRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,2-dichloro-4'-methylacetophenone (4974-59-8) → 4-methylphenylglyoxal (1075-47-4)

Guidance literature:

With water; sodium carbonate; Heating;

Reference yield: 67.0%

(S)-1-(4-methylphenyl)-1,2-ethanediol (139016-20-9,146566-05-4) → 4-methylphenylglyoxal (1075-47-4) + 2-hydroxy-1-p-tolyl-ethanone (4079-54-3)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; at 20 ℃; for 5h; ultrasound;

DOI:10.1016/j.tetlet.2004.12.073

Reference yield: 45.0%

p-methylphenacyl chloride (4209-24-9) → 4-methylphenylglyoxal (1075-47-4)

Guidance literature:

With 2-Pyridone; at 20 ℃;

upstream raw materials:

2,2-dichloro-4'-methylacetophenone

dichloroacethyl chloride

toluene

p-methylphenacyl chloride

Downstream raw materials:

p-tolyl-glyoxal-bis-phenylhydrazone

2-morpholin-4-ylimino-1-p-tolyl-ethanone

[3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-3a-methyl-hexahydro-furo[2,3-d]thiazol-2-yl]-p-tolyl-methanone

[9-(2-hydroxy-ethyl)-2,9a-dimethyl-5,9,9a,10-tetrahydro-pyrimido[4,5-d]thiazolo[3,4-a]pyrimidin-7-yl]-p-tolyl-methanone

Refernces

• 1、 Latifi, Mahsa,Talebdizaeh, Mahdiyeh,Anary-Abbasinejad, Mohammad. "Reactions of cyclohexyl isocyanide, dialkyl acetylenedicarboxylates and 1-aryl-2-ene-3-acetyl-1,4-diketones: One-pot synthesis of highly functionalized 5-cyclohexylimino-2,5-dihydrofurans". . p. 66 - 72. Retrieved 2018/10/26.
• 2、 Dutta, Sayan,Kotha, Surya Srinivas,Sekar, Govindasamy. "Metal free one-pot synthesis of α-ketoamides from terminal alkenes". . p. 47265 - 47269. Retrieved 2015/06/16.