1-(4-(Bromomethyl)phenyl)ethanone

Base Information

• Chemical Name: 1-(4-(Bromomethyl)phenyl)ethanone
• CAS No.: 51229-51-7
• Molecular Formula: C9H9BrO
• Molecular Weight: 213.074
• Hs Code.: 2914700090
• Mol file: 51229-51-7.mol

Synonyms:1-(4-Bromomethylphenyl)ethanone;4-Acetylbenzyl bromide;4'-(Bromomethyl)acetophenone;p-(Bromomethyl)acetophenone;p-Acetylbenzylbromide;1-(4-(bromomethyl)phenyl)ethanone;

Chemical Property of 1-(4-(Bromomethyl)phenyl)ethanone

Chemical Property:

• Vapor Pressure: 0.00195mmHg at 25°C
• Melting Point: 38.5-40.0℃
• Refractive Index: 1.563
• Boiling Point: 291.4 °C at 760 mmHg
• Flash Point: 94.1 °C
• PSA: 17.07000
• Density: 1.416 g/cm³
• LogP: 2.78410
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

≥99.0% ^*data from raw suppliers

1-(4-(Bromomethyl)phenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(4-(Bromomethyl)phenyl)ethanone is useful in the synthesis of series of dihydropyrimidine and thiopyrimidine derivatives as antiviral agents.

Technology Process of 1-(4-(Bromomethyl)phenyl)ethanone

There total 9 articles about 1-(4-(Bromomethyl)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(bromomethyl)-4-ethynylbenzene → 4-acetylbenzyl bromide (51229-51-7)

Guidance literature:

With water; In methanol; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.joc.0c02641

Reference yield: 95.0%

para-methylacetophenone (122-00-9) → 4-acetylbenzyl bromide (51229-51-7)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In acetonitrile; at 90 ℃; for 1.5h;

DOI:10.1021/ja056358i

Reference yield: 86.0%

2,2'-azobis(isobutyronitrile) (78-67-1) + para-methylacetophenone (122-00-9) → 4-acetylbenzyl bromide (51229-51-7)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 90 ℃; for 1.5h; Inert atmosphere;

upstream raw materials:

para-methylacetophenone

4-(hydroxymethyl)acetophenone

toluene

4-methylethylbenzene

Downstream raw materials:

1-(4-Prop-2-ynyloxymethyl-phenyl)-ethanone

4-acetyl benzylphosphonate de diethyle

1-{4-[(phenylthio)methyl]phenyl}ethan-1-one

p-(4-methoxyphenoxymethyl)acetophenone

Refernces

• 1、 -. "Photocatalytic continuous bromination method". Paragraph 0068-0069. . Retrieved 2021/04/03.
• 2、 Dong, Ying,Li, Wen-Han,Dong, Yu-Bin. "Dual-Metal N-Heterocyclic Carbene Complex (M = Au and Pd)-Functionalized UiO-67 MOF for Alkyne Hydration-Suzuki Coupling Tandem Reaction". . p. 1818 - 1826. Retrieved 2021/01/13.