4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE

Base Information

• Chemical Name: 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE
• CAS No.: 663194-10-3
• Molecular Formula: C8H10BrN3O
• Molecular Weight: 244.091
• Hs Code.: 2934999090
• Mol file: 663194-10-3.mol

Synonyms:4-(4-Bromopyrimidin-2-yl)morpholine;

Chemical Property of 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE

Chemical Property:

• Vapor Pressure: 4.6E-06mmHg at 25°C
• Refractive Index: 1.583
• Boiling Point: 382.8 °C at 760 mmHg
• Flash Point: 185.3 °C
• PSA: 38.25000
• Density: 1.57 g/cm³
• LogP: 1.14070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-(4-Bromopyrimidin-2-yl)morpholine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE

There total 2 articles about 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-Hydroxy-2-morpholino-pyrimidin (19810-79-8) → 4-(4-bromopyrimidin-2-yl)morpholine (663194-10-3)

Guidance literature:

With phosphorus(V) oxybromide; In acetonitrile; for 1h; Heating / reflux;

Reference yield: 19.0%

morpholine (110-91-8,99108-56-2) + 2,4-dibromo-pyrimidine (3921-01-5) → 4-(4-bromopyrimidin-2-yl)morpholine (663194-10-3) + 4-(2-bromopyrimidin-4-yl)morpholine (1209459-32-4)

Guidance literature:

2,4-dibromo-pyrimidine; With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

morpholine; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.ejmech.2017.10.007

Reference yield: 53.0%

4-(4-bromopyrimidin-2-yl)morpholine (663194-10-3) + 2‐amino‐5‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)benzonitrile (934426-22-9) → 2-amino-5-(2-morpholinopyrimidin-4-yl)benzonitrile

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 130 ℃; for 0.25h; Inert atmosphere; Microwave irradiation; Sealed tube;

DOI:10.1016/j.ejmech.2017.10.007

upstream raw materials:

4-Hydroxy-2-morpholino-pyrimidin

morpholine

2,4-dibromo-pyrimidine

Refernces

• 1、 -. "1,4-DISUBSTITUTED ISOQUINILONE DERIVATIVES AS RAF-KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES". Page/Page column 50-51. . Retrieved 2010/02/11.