2-bromo-3-phenylpropionyl chloride

Base Information

• Chemical Name: 2-bromo-3-phenylpropionyl chloride
• CAS No.: 81136-07-4
• Molecular Formula: C₉H₈BrClO
• Molecular Weight: 247.519
• Mol file: 81136-07-4.mol

Synonyms:

Chemical Property of 2-bromo-3-phenylpropionyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-3-phenylpropionyl chloride

There total 11 articles about 2-bromo-3-phenylpropionyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-3-phenylpropanoic acid (16503-53-0) → 2-bromo-3-phenylpropionyl chloride (81136-07-4,42762-86-7)

Guidance literature:

With phosphorus pentachloride; inactive α-bromo-β-phenyl-propionyl chloride;

Reference yield:

hydrocinnamic acid chloride (645-45-4) → 2-bromo-3-phenylpropionyl chloride (81136-07-4,42762-86-7)

Guidance literature:

With bromine; at 65 - 70 ℃;

DOI:10.1021/ja01271a039

Reference yield:

Phenylalanine (150-30-1,25191-15-5,658-69-5,67675-33-6) → 2-bromo-3-phenylpropionyl chloride (81136-07-4,42762-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite; hydrogen bromide; potassium bromide / -13 °C

2: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

With thionyl chloride; hydrogen bromide; N,N-dimethyl-formamide; potassium bromide; sodium nitrite; In dichloromethane;

DOI:10.1080/00397911.2011.608142

upstream raw materials:

2-bromo-3-phenylpropanoic acid

hydrocinnamic acid chloride

3-Phenylpropionic acid

bromine

Downstream raw materials:

N-Ξ-phenylalanyl-L-tyrosine

methyl 2-bromo-3-phenylpropionate

α-bromo-β-phenylpropionamide

benzyl 2-bromo-3-phenylpropanoate

Refernces

• 1、 Xue, Xiaoqian,Zhang, Yan,Wang, Chao,Zhang, Maofeng,Xiang, Qiuping,Wang, Junjian,Wang, Anhui,Li, Chenchang,Zhang, Cheng,Zou, Lingjiao,Wang, Rui,Wu, Shuang,Lu, Yongzhi,Chen, Hongwu,Ding, Ke,Li, Guohui,Xu, Yong. "Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer". . p. 542 - 559. Retrieved 2018/05/24.
• 2、 Tka, Najeh,Kraem, Jamil,Hassine, Bechir Ben. "Synthesis of enantiomerically enriched-bromonitriles from amino acids". . p. 735 - 743. Retrieved 2013/01/15.