3-AMINO-4-METHYLBENZYL ALCOHOL

Base Information

• Chemical Name: 3-AMINO-4-METHYLBENZYL ALCOHOL
• CAS No.: 81863-45-8
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• Hs Code.: 2922199090
• Mol file: 81863-45-8.mol

Synonyms:3-AMINO-4-METHYLBENZYL ALCOHOL;(3-Amino-4-methylphenyl)methanol;3-AMino-4-Methylbenzyl alcohol 97%

Chemical Property of 3-AMINO-4-METHYLBENZYL ALCOHOL

Chemical Property:

• Vapor Pressure: 0.000605mmHg at 25°C
• Melting Point: 107-109 °C(lit.)
• Refractive Index: 1.601
• Boiling Point: 297.5 °C at 760 mmHg
• PKA: 14.53±0.10(Predicted)
• Flash Point: 133.7 °C
• PSA: 46.25000
• Density: 1.126 g/cm³
• LogP: 1.65070
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

(3-Amino-4-methylphenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3-Amino-4-methylbenzyl alcohol was used in the preparation of 3-(acetyloxymethyl)-6-methylacetanilide.

Technology Process of 3-AMINO-4-METHYLBENZYL ALCOHOL

There total 5 articles about 3-AMINO-4-METHYLBENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-amino-4-methyl benzoic acid methyl ester (18595-18-1) → 3-(hydroxymethyl)-6-methylaniline (81863-45-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1002/cmdc.202000303

Reference yield: 85.0%

(4-Methyl-3-nitro-phenyl)-methanol (40870-59-5) → 3-(hydroxymethyl)-6-methylaniline (81863-45-8)

Guidance literature:

With titanium(III) chloride; In tetrahydrofuran; water; for 0.116667h; Ambient temperature;

Reference yield:

4-methyl-3-nitro-benzoic acid methyl ester (7356-11-8) → 3-(hydroxymethyl)-6-methylaniline (81863-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium chloride; iron / water; ethanol / 3 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; iron; ammonium chloride; In tetrahydrofuran; ethanol; water;

DOI:10.1002/cmdc.202000303

upstream raw materials:

(4-Methyl-3-nitro-phenyl)-methanol

4-methyl-3-nitrobenzaldehyde

3-amino-4-methyl benzoic acid methyl ester

4-methyl-3-nitrobenzoic acid

Downstream raw materials:

5-amino-2-iodo-4-methylbenzyl alcohol

[(E)-Methoxyimino]-{2-methyl-5-[1-(3-trifluoromethoxy-phenyl)-eth-(E)-ylideneaminooxymethyl]-phenyl}-acetic acid methyl ester

[(E)-Methoxyimino]-{2-methyl-5-[1-(3-trimethylsilanyl-phenyl)-eth-(E)-ylideneaminooxymethyl]-phenyl}-acetic acid methyl ester

{5-[1-(3,5-Dichloro-phenyl)-eth-(E)-ylideneaminooxymethyl]-2-methyl-phenyl}-[(E)-methoxyimino]-acetic acid methyl ester

Refernces

• 1、 -. "Potassium channel openers". . . Retrieved 2008/06/13.
• 2、 -. "SUBSTITUTED 4-AMINOQUINOLINE DERIVATIVES AS GASTRIC ACID SECRETION INHIBITORS". . . Retrieved 2008/06/13.