7-amino-8-methylquinoline-3-carbaldehyde

Base Information

• Chemical Name: 7-amino-8-methylquinoline-3-carbaldehyde
• CAS No.: 521074-55-5
• Molecular Formula: C11H10 N2 O
• Molecular Weight: 186.21000
• Hs Code.: 2933499090
• Mol file: 521074-55-5.mol

Synonyms:7-Amino-8-methyl-3-quinolinecarboxaldehyde

Chemical Property of 7-amino-8-methylquinoline-3-carbaldehyde

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 405.758oC at 760 mmHg
• Flash Point: 199.195oC
• PSA: 55.98000
• Density: 1.267g/cm3
• LogP: 2.51910

Purity/Quality:

98%min ^*data from raw suppliers

7-Amino-8-methylquinoline-3-carbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-amino-8-methylquinoline-3-carbaldehyde

There total 1 articles about 7-amino-8-methylquinoline-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2,6-toluenediamine (823-40-5) + 2-dimethylaminomethylene-1,3-bis(dimethylimmonio)propane bistetrafluoroborate → 7-amino-8-methylquinoline-3-carboxaldehyde (521074-55-5)

Guidance literature:

2,6-toluenediamine; 2-dimethylaminomethylene-1,3-bis(dimethylimmonio)propane bistetrafluoroborate; In isopropyl alcohol; for 16h; Reflux;

With hydrogenchloride; In water; at 20 - 70 ℃; for 5h;

With potassium carbonate; In water; ethyl acetate; at 90 ℃; for 16h;

DOI:10.1021/jm300167z

Reference yield:

7-amino-8-methylquinoline-3-carboxaldehyde (521074-55-5) + 4-(cyclopropylmethoxy)benzoyl chloride (1284199-22-9) → 4-(cyclopropylmethoxy)-N-(3-formyl-8-methylquinolin-7-yl)benzamide (1018856-62-6)

Guidance literature:

With pyridine; at 15 - 30 ℃; Cooling with ice;

Reference yield:

7-amino-8-methylquinoline-3-carboxaldehyde (521074-55-5) + p-(2-cyclopropylethoxy)benzoyl chloride (756478-85-0) → 4-(2-cyclopropylethoxy)-N-(3-formyl-8-methylquinolin-7-yl)benzamide (1018856-65-9)

Guidance literature:

With pyridine; at 15 - 30 ℃; for 16h;

upstream raw materials:

2,6-toluenediamine

Downstream raw materials:

4-(2-cyclopropylethoxy)-N-(3-formyl-8-methylquinolin-7-yl)benzamide

4-(cyclopropylmethoxy)-N-(3-formyl-8-methylquinolin-7-yl)benzamide

4-(2-cyclopropylethoxy)-2-fluoro-N-(3-formyl-8-methylquinolin-7-yl)benzamide

4-(2-cyclopropylethoxy)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide

Refernces

• 1、 -. "QUINOLINE COMPOUND". Page 65. . Retrieved 2010/02/08.