2-methyl-2-(4-methylphenyl)-1,3-dithiane

Base Information

• Chemical Name: 2-methyl-2-(4-methylphenyl)-1,3-dithiane
• CAS No.: 56637-45-7
• Molecular Formula: C12H16 S2
• Molecular Weight: 224.391
• Mol file: 56637-45-7.mol

Synonyms:2-Methyl-2-(4-methylphenyl)-1,3-dithiane;2-Methyl-2-p-tolyl-1,3-dithiane

Chemical Property of 2-methyl-2-(4-methylphenyl)-1,3-dithiane

Chemical Property:

• Vapor Pressure: 0.000135mmHg at 25°C

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-2-(4-methylphenyl)-1,3-dithiane

There total 4 articles about 2-methyl-2-(4-methylphenyl)-1,3-dithiane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1.3-propanedithiol (109-80-8) + para-methylacetophenone (122-00-9) → 2-methyl-2-(4-methylphenyl)-1,3-dithiane (56637-45-7)

Guidance literature:

With P-benzyltriphenylphosphonium tribromide; at 20 ℃; for 1.7h;

DOI:10.1080/00397910802219197

Reference yield: 86.0%

2-chloro-1,3-dithiane (57529-04-1) + 4-n-methylphenylacetylene (766-97-2) → 2-methyl-2-(4-methylphenyl)-1,3-dithiane (56637-45-7)

Guidance literature:

With methanesulfonic acid; In methanol; 1,2-dichloro-ethane; at 50 ℃; for 8h; regioselective reaction;

DOI:10.1039/c7ob00795g

Reference yield: 85.0%

1.3-propanedithiol (109-80-8) + 2-(p-tolyl)-2-methyl-1,3-dioxolane (6135-56-4) → 2-methyl-2-(4-methylphenyl)-1,3-dithiane (56637-45-7)

Guidance literature:

zirconium(IV) chloride; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1055/s-1999-2609

upstream raw materials:

1.3-propanedithiol

para-methylacetophenone

2-(p-tolyl)-2-methyl-1,3-dioxolane

4-methylacethophenone oxime

Downstream raw materials:

2-p-tolyl-6,7-dihydro-5H-[1,4]dithiepine

2-methyl-2-(4-methylphenyl)-2-methyl-1,3-dithiolane

2-p-tolyl-[1,4]dithiepane

para-methylacetophenone

Refernces

• 1、 Liu, Teng,Tian, Lixia,Lai, Junshan,Min, Deng,Qu, Mengnan,Tang, Shouchu. "Alcohol-mediated direct dithioacetalization of alkynes with 2-chloro-1,3-dithiane for the synthesis of Markovnikov dithianes". supporting information. p. 4068 - 4071. Retrieved 2017/07/10.
• 2、 Karimi, Babak,Vafaeezadeh, Majid. "SBA-15 functionalized sulfonic acid containing a confined hydrophobic and acidic ionic liquid: A highly efficient catalyst for solvent-free thioacetalization of carbonyl compounds at room temperature". . p. 23207 - 23211. Retrieved 2013/11/19.