Amuvatinib

Base Information

• Chemical Name: Amuvatinib
• CAS No.: 850879-09-3
• Molecular Formula: C₂₃H₂₁N₅O₃S
• Molecular Weight: 447.517
• UNII: SO9S6QZB4R
• ChEMBL ID: CHEMBL2103851
• DSSTox Substance ID: DTXSID50234176
• Metabolomics Workbench ID: 153674
• NCI Thesaurus Code: C71750
• Nikkaji Number: J3.304.639A
• Wikidata: Q27074458
• Mol file: 850879-09-3.mol

Synonyms:amuvatinib;HPK 56;HPK-56;HPK56;MP 470;MP-470;MP470;N-(1,3-benzodioxol-5-ylmethyl)-4-(benzofuro(3,2-d)pyrimidin-4-yl)piperazine-1- carbothioamide

Chemical Property of Amuvatinib

Chemical Property:

• Boiling Point: 649.5 °C at 760 mmHg
• Flash Point: 346.6 °C
• PSA: 115.02000
• Density: 1.443 g/cm³
• LogP: 3.71560
• Solubility.: ≥22.4 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 447.13651072
• Heavy Atom Count: 32
• Complexity: 678

Purity/Quality:

98%,99%, ^*data from raw suppliers

Amuvatinib ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1C2=NC=NC3=C2OC4=CC=CC=C43)C(=S)NCC5=CC6=C(C=C5)OCO6
• Recent ClinicalTrials: Safety of MP470 in Combination With Standard-of-Care Chemotherapy Regimens to Treat Solid Tumors
• Description: Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Phase 2. Amuvatinib is a multi-targeted inhibitor of receptor tyrosine kinases that inhibits c-Kit, platelet-derived growth factor receptor α (PDGFRα), and c-Met (IC50s = 10, 40, and 81 nM, respectively). It inhibits growth and induces apoptosis in prostate cancer cell lines, with additive effects achieved when combined with erlotinib . Amuvatinib sensitizes cancer cells to radiation and chemotherapeutic compounds, in part by inhibiting homologous recombination.
• Uses: MP-470 (Amuvatinib) is a potent and multi-targeted inhibitor of c-KitD816H, PDGFαV561D and Flt3D835Y with IC50 of 10 nM, 40 nM and 81 nM, respectively.

Technology Process of Amuvatinib

There total 1 articles about Amuvatinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

· 4-(Piperazin-1-yl)benzo[4,5]furo[3,2-d]pyrimidine (380339-27-5) + N-benzo[1,3]dioxol-5-ylmethyl-thioformamide chloride (1015482-56-0) → Amuvatinib (850879-09-3)

Guidance literature:

With pyridine; In dichloromethane;

upstream raw materials:

· 4-(Piperazin-1-yl)benzo[4,5]furo[3,2-d]pyrimidine

N-benzo[1,3]dioxol-5-ylmethyl-thioformamide chloride

Refernces