tert-Butyl (azetidin-3-yl)carbamate hydrochloride

Base Information

• Chemical Name: tert-Butyl (azetidin-3-yl)carbamate hydrochloride
• CAS No.: 217806-26-3
• Molecular Formula: C8H16N2O2^.HCl
• Molecular Weight: 208.688
• Hs Code.: 2933990090
• Mol file: 217806-26-3.mol

Synonyms:tert-Butyl (azetidin-3-yl)carbamate hydrochloride;

Chemical Property of tert-Butyl (azetidin-3-yl)carbamate hydrochloride

Chemical Property:

• Vapor Pressure: 0.0081mmHg at 25°C
• Refractive Index: 1.48
• Boiling Point: 303 °C at 760 mmHg
• Flash Point: 137.1 °C
• PSA: 50.36000
• Density: 1.06g/cm³
• LogP: 2.00460
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

3-N-Boc-aminoazetidine HCl ^*data from reagent suppliers

Safty Information:

• Statements: 52

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl (azetidin-3-yl)carbamate hydrochloride

There total 3 articles about tert-Butyl (azetidin-3-yl)carbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl (1-benzhydrylazetidin-3-yl)carbamate hydrochloride salt → tert-butyl N-(azetidin-3-yl)carbamate hydrochloride (217806-26-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 40 ℃; for 48h; under 3000.3 Torr; Industrial scale;

DOI:10.1021/acs.oprd.1c00263

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-(azetidin-3-yl)carbamate hydrochloride (217806-26-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / water; Isopropyl acetate / 6 h / 20 °C / Industrial scale

2: hydrogenchloride / Isopropyl acetate / 1 h / 10 °C / Industrial scale

3: hydrogen; palladium 10% on activated carbon / methanol / 48 h / 40 °C / 3000.3 Torr / Industrial scale

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; Isopropyl acetate; water;

DOI:10.1021/acs.oprd.1c00263

Reference yield:

tert-butyl (1-benzhydrylazetidin-3-yl)carbamate (91189-18-3) → tert-butyl N-(azetidin-3-yl)carbamate hydrochloride (217806-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / Isopropyl acetate / 1 h / 10 °C / Industrial scale

2: hydrogen; palladium 10% on activated carbon / methanol / 48 h / 40 °C / 3000.3 Torr / Industrial scale

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; Isopropyl acetate;

DOI:10.1021/acs.oprd.1c00263

upstream raw materials:

di-tert-butyl dicarbonate

tert-butyl (1-benzhydrylazetidin-3-yl)carbamate

Downstream raw materials:

tert-butyl (1-(pyridin-2-yl)azetidin-3-yl)carbamate

Refernces