2-N-BOC-6-N-CBZ-D-LYSINOL

Base Information

• Chemical Name: 2-N-BOC-6-N-CBZ-D-LYSINOL
• CAS No.: 252940-35-5
• Molecular Formula: C₁₉H₃₀N₂O₅
• Molecular Weight: 366.458
• Hs Code.: 2924299090
• Mol file: 252940-35-5.mol

Synonyms:(R)-(5-tert-Butoxycarbonylamino-6-hydroxyhexyl)carbamic acid benzyl ester

Chemical Property of 2-N-BOC-6-N-CBZ-D-LYSINOL

Chemical Property:

• Vapor Pressure: 5.42E-13mmHg at 25°C
• Boiling Point: 551.4oC at 760 mmHg
• PKA: 12.06±0.46(Predicted)
• Flash Point: 287.3°C
• PSA: 96.89000
• Density: 1.122g/cm³
• LogP: 3.75050
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-N-Boc-6-n-cbz-d-lysinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-N-BOC-6-N-CBZ-D-LYSINOL

There total 9 articles about 2-N-BOC-6-N-CBZ-D-LYSINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Boc-L-Lys(Z)-OMe (73548-77-3) → N6-benzyloxycarbonyl-N2-tert-butoxycarbonyl-L-lysinol (82689-20-1,252940-35-5)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 48h;

DOI:10.1002/ejoc.201500144

Reference yield: 92.0%

Boc-Lys(Z)-OH (2389-45-9) → N6-benzyloxycarbonyl-N2-tert-butoxycarbonyl-L-lysinol (82689-20-1,252940-35-5)

Guidance literature:

Boc-Lys(Z)-OH; With 4-methyl-morpholine; isobutyl chloroformate;

With sodium tetrahydroborate;

DOI:10.1016/j.tetasy.2015.09.012

Reference yield:

aqueous sodium chloride + Boc-L-Lys(Z)-OMe (73548-77-3) → N6-benzyloxycarbonyl-N2-tert-butoxycarbonyl-L-lysinol (82689-20-1,252940-35-5)

Guidance literature:

With sodium borohydrid; lithium chloride; In tetrahydrofuran; ethanol; water;

upstream raw materials:

Boc-L-Lys(Z)-OMe

C₂₄H₃₆N₂O₈

Boc-Lys(Z)-OH

methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride

Refernces

• 1、 Baldwin, Christopher R.,Birmingham, William R.,Flitsch, Sabine L.,Ford, Grayson J.,Hepworth, Lorna J.,Huang, Min,Kress, Nico,Marshall, James R.,Mattey, Ashley P.,Seibt, Lisa S.,Turner, Nicholas J.. "Synthesis of protected 3-aminopiperidine and 3-aminoazepane derivatives using enzyme cascades". supporting information. p. 7949 - 7952. Retrieved 2020/09/09.
• 2、 Schiesser, Stefan,Hackner, Benjamin,Vrabel, Milan,Beck, Wolfgang,Carell, Thomas. "Synthesis and DNA-damaging properties of cisplatin-N-mustard conjugates". supporting information. p. 2654 - 2660. Retrieved 2015/04/27.