8-Bromo-6-chloroimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 8-Bromo-6-chloroimidazo[1,2-a]pyridine
• CAS No.: 957187-27-8
• Molecular Formula: C7H4BrClN2
• Molecular Weight: 231.479
• Hs Code.: 2933990090
• Mol file: 957187-27-8.mol

Synonyms:8-Bromo-6-chloroimidazo[1,2-a]pyridine

Chemical Property of 8-Bromo-6-chloroimidazo[1,2-a]pyridine

Chemical Property:

• Melting Point: 125-128℃
• PSA: 17.30000
• Density: 1.84 g/cm³
• LogP: 2.75020
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-Bromo-6-chloroimidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-Bromo-6-chloroimidazo[1,2-a]pyridine is used as an organic chemical synthesis intermediate.

Technology Process of 8-Bromo-6-chloroimidazo[1,2-a]pyridine

There total 2 articles about 8-Bromo-6-chloroimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-chloroethanal (107-20-0) + 2-amino-3-bromo-5-chloropyridine (26163-03-1) → 6-chloro-8-bromoimidazo[1,2-a]pyridine (957187-27-8)

Guidance literature:

In ethanol; water; at 50 ℃;

Reference yield:

2-amino-3-bromo-5-chloropyridine (26163-03-1) + Bromoacetaldehyde diethyl acetal (2032-35-1) → 6-chloro-8-bromoimidazo[1,2-a]pyridine (957187-27-8)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; at 80 ℃;

Reference yield:

6-chloro-8-bromoimidazo[1,2-a]pyridine (957187-27-8) + phenylmethanethiol (100-53-8) → 8-(benzylthio)-6-chloroimidazo[1,2-a]pyridine

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; In toluene; at 100 ℃; for 2h; Inert atmosphere;

upstream raw materials:

2-chloroethanal

2-amino-3-bromo-5-chloropyridine

Bromoacetaldehyde diethyl acetal

Refernces

• 1、 -. "HETEROCYCLIC COMPOUND". Paragraph 1139; 1140; 1141. . Retrieved 2019/06/17.
• 2、 -. "S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS". Page/Page column 74. . Retrieved 2011/06/26.