5-Bromo-2-chlorobenzothiazole

Base Information

• Chemical Name: 5-Bromo-2-chlorobenzothiazole
• CAS No.: 824403-26-1
• Molecular Formula: C7H3BrClNS
• Molecular Weight: 248.53
• Hs Code.: 29342000
• Mol file: 824403-26-1.mol

Synonyms:benzothiazole, 5-bromo-2-chloro-;5-Bromo-2-chloro-1,3-benzothiazole;

Chemical Property of 5-Bromo-2-chlorobenzothiazole

Chemical Property:

• Vapor Pressure: 0.00118mmHg at 25°C
• Refractive Index: 1.721
• Boiling Point: 309.2 °C at 760 mmHg
• PKA: -0.73±0.10(Predicted)
• Flash Point: 140.8 °C
• PSA: 41.13000
• Density: 1.849 g/cm³
• LogP: 3.71220
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-2-chloro-1,3-benzothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-2-chlorobenzothiazole

There total 3 articles about 5-Bromo-2-chlorobenzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.96%

5-bromo-1,3-benzothiazol-2(3H)-one (199475-45-1) → 5-bromo-2-chlorobenzo[d]thiazole (824403-26-1)

Guidance literature:

With trichlorophosphate; at 110 ℃; for 32h;

Reference yield:

2-amino-4-bromobenzenethiol (93933-49-4) → 5-bromo-2-chlorobenzo[d]thiazole (824403-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 2 h / 25 - 50 °C / Inert atmosphere

2: trichlorophosphate / 32 h / 110 °C

With trichlorophosphate; In tetrahydrofuran;

Reference yield:

→ 5-bromo-2-chlorobenzo[d]thiazole (824403-26-1)

Guidance literature:

upstream raw materials:

2-amino-4-bromobenzenethiol

5-bromo-1,3-benzothiazol-2(3H)-one

Downstream raw materials:

5‐bromo‐1,3‐benzothiazol‐2‐amine

Refernces

• 1、 -. "BICYCLIC HETEROAROMATIC DERIVATIVES AS MODULATORS OF CXCR3 FUNCTION". Page 40. . Retrieved 2010/02/10.