6-(2-N-methylaminobenzoyl)-5,7-dimethoxy-2,2-dimethylchromene

Base Information

• Chemical Name: 6-(2-N-methylaminobenzoyl)-5,7-dimethoxy-2,2-dimethylchromene
• CAS No.: 79228-40-3
• Molecular Formula: C₂₁H₂₃NO₄
• Molecular Weight: 353.418
• Mol file: 79228-40-3.mol

Synonyms:

Chemical Property of 6-(2-N-methylaminobenzoyl)-5,7-dimethoxy-2,2-dimethylchromene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(2-N-methylaminobenzoyl)-5,7-dimethoxy-2,2-dimethylchromene

There total 9 articles about 6-(2-N-methylaminobenzoyl)-5,7-dimethoxy-2,2-dimethylchromene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-3-methylbut-1-yne (1111-97-3) → 6-(2-N-methylaminobenzoyl)-5,7-dimethoxy-2,2-dimethylchromene (79228-40-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 2.11 g / K₂CO₃, KI / acetone / 20 h / Heating

2: 1.) Li, n-bromobutane / 1.) ether, 2.5 h, 2.) ether, reflux, 20 h

3: 455 mg / diethyl ether / 3 h / Heating

4: 958 mg / NaH / dimethylsulfoxide / 20 h / Ambient temperature

5: KOH / methanol / 1 h / Heating

With 1-bromo-butane; potassium hydroxide; lithium; sodium hydride; potassium carbonate; potassium iodide; In methanol; diethyl ether; dimethyl sulfoxide; acetone;

DOI:10.1016/S0040-4020(01)97737-3

Reference yield:

3,5-dimethoxyphenol (500-99-2) → 6-(2-N-methylaminobenzoyl)-5,7-dimethoxy-2,2-dimethylchromene (79228-40-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 2.11 g / K₂CO₃, KI / acetone / 20 h / Heating

2: 1.) Li, n-bromobutane / 1.) ether, 2.5 h, 2.) ether, reflux, 20 h

3: 455 mg / diethyl ether / 3 h / Heating

4: 958 mg / NaH / dimethylsulfoxide / 20 h / Ambient temperature

5: KOH / methanol / 1 h / Heating

With 1-bromo-butane; potassium hydroxide; lithium; sodium hydride; potassium carbonate; potassium iodide; In methanol; diethyl ether; dimethyl sulfoxide; acetone;

DOI:10.1016/S0040-4020(01)97737-3

Reference yield:

5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (21421-66-9) → 6-(2-N-methylaminobenzoyl)-5,7-dimethoxy-2,2-dimethylchromene (79228-40-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) Li, n-bromobutane / 1.) ether, 2.5 h, 2.) ether, reflux, 20 h

2: 455 mg / diethyl ether / 3 h / Heating

3: 958 mg / NaH / dimethylsulfoxide / 20 h / Ambient temperature

4: KOH / methanol / 1 h / Heating

With 1-bromo-butane; potassium hydroxide; lithium; sodium hydride; In methanol; diethyl ether; dimethyl sulfoxide;

DOI:10.1016/S0040-4020(01)97737-3

upstream raw materials:

N-Methylisatoic anhydride

6-(2-N,N-acetylmethylaminobenzoyl)-5,7-dimethoxy-2,2-dimethylchromene

3-chloro-3-methylbut-1-yne

3,5-dimethoxyphenol

Downstream raw materials:

acronine

isoacronycine

Refernces