NSC 176404

Base Information

• Chemical Name: NSC 176404
• CAS No.: 73040-60-5
• Molecular Formula: C9H7BrN2S
• Molecular Weight: 255.138
• Mol file: 73040-60-5.mol

Synonyms:NSC 176404

Chemical Property of NSC 176404

Chemical Property:

• Melting Point: 205-206 oC
• Boiling Point: 410.9 °C at 760 mmHg
• Flash Point: 202.3 °C
• PSA: 67.88000
• Density: 1.636 g/cm³
• LogP: 3.08490

Purity/Quality:

99% ^*data from raw suppliers

5-(4-Bromophenyl)thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NSC 176404

There total 6 articles about NSC 176404 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-(4-bromophenyl)-2-nitrothiazole → 2-amino-5-(4-bromophenyl)thiazole (73040-60-5)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at 20 ℃; for 13h; chemoselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1002/anie.201604026

Reference yield:

2-bromo-2-(4-bromophenyl)acetaldehyde + thiourea (17356-08-0) → 2-amino-5-(4-bromophenyl)thiazole (73040-60-5)

Guidance literature:

In ethanol; at 90 ℃; for 6h;

Reference yield:

1-(p-bromophenyl)-2,2-dichloroethanol (61693-77-4) + thiourea (17356-08-0) → 2-amino-5-(4-bromophenyl)thiazole (73040-60-5)

Guidance literature:

With potassium hydroxide; In methanol;

upstream raw materials:

1-(p-bromophenyl)-2,2-dichloroethanol

thiourea

4-bromophenethanol

p-bromophenylacetaldehyde

Downstream raw materials:

N-[5-(4-bromo-phenyl)-thiazol-2-yl]-acetamide

Refernces

• 1、 -. "FE NANOPARTICLES WITH PPM CONTENTS OF PD, CU AND/OR NI, REACTIONS IN WATER CATALYZED BY THEM". Paragraph 0084; 0100. . Retrieved 2017/07/14.
• 2、 Feng, Jie,Handa, Sachin,Gallou, Fabrice,Lipshutz, Bruce H.. "Safe and Selective Nitro Group Reductions Catalyzed by Sustainable and Recyclable Fe/ppm Pd Nanoparticles in Water at Room Temperature". supporting information. p. 8979 - 8983. Retrieved 2016/07/26.