3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide

Base Information

• Chemical Name: 3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide
• CAS No.: 850607-58-8
• Molecular Formula: C24H29N2.Br
• Molecular Weight: 425.40400
• Mol file: 850607-58-8.mol

Synonyms:Darotropium bromide;

Chemical Property of 3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide

Chemical Property:

• PSA: 23.79000
• LogP: 1.86658

Purity/Quality:

99% ^*data from raw suppliers

3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octanebromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide

There total 3 articles about 3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

methyl bromide (74-83-9) + 3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile (850607-53-3) → Darotropium bromide (850607-58-8)

Guidance literature:

In tert-butyl methyl ether; acetone; at 20 ℃; for 1h;

DOI:10.1021/jm900736e

Reference yield:

3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile (850607-53-3) → Darotropium bromide (850607-58-8)

Guidance literature:

With methyl bromide;

DOI:10.1016/j.bmcl.2009.07.006

Reference yield:

→ Darotropium bromide (850607-58-8)

Guidance literature:

upstream raw materials:

methyl bromide

3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile

Refernces

• 1、 -. "NOVEL COMBINATION OF THERAPEUTIC AGENTS". Page/Page column 16-17. . Retrieved 2009/04/25.
• 2、 Wan, Zehong,Laine, Dramane I.,Yan, Hongxing,Zhu, Chongjie,Widdowson, Katherine L.,Buckley, Peter T.,Burman, Miriam,Foley, James J.,Sarau, Henry M.,Schmidt, Dulcie B.,Webb, Edward F.,Belmonte, Kristen E.,Palovich, Michael. "Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD". scheme or table. p. 4560 - 4562. Retrieved 2010/04/24.