N-(3-Cyanophenyl)-N-(4-methoxyphenyl)amine

Base Information

• Chemical Name: N-(3-Cyanophenyl)-N-(4-methoxyphenyl)amine
• CAS No.: 458550-48-6
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 224.262
• Hs Code.: 2926909090
• Mol file: 458550-48-6.mol

Synonyms:N-(3-Cyanophenyl)-N-(4-methoxyphenyl)amine

Chemical Property of N-(3-Cyanophenyl)-N-(4-methoxyphenyl)amine

Chemical Property:

• Vapor Pressure: 4.99E-06mmHg at 25°C
• Boiling Point: 381.7oC at 760 mmHg
• Flash Point: 184.6°C
• PSA: 45.05000
• Density: 1.17g/cm³
• LogP: 3.38348
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

N-(3-Cyanophenyl)-N-(4-methoxyphenyl)amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-Cyanophenyl)-N-(4-methoxyphenyl)amine

There total 4 articles about N-(3-Cyanophenyl)-N-(4-methoxyphenyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-chloromethoxybenzene (623-12-1) + m-cyanoaniline (2237-30-1) → 3-(4-methoxy-phenylamino)-benzonitrile (458550-48-6)

Guidance literature:

With potassium phosphate; water; palladium diacetate; XPhos; In tert-butyl alcohol; at 110 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol801285g

Reference yield: 72.0%

4-methoxyphenyl magnesium bromide (13139-86-1) + 3-nitrobenzonitrile (619-24-9) → 3-(4-methoxy-phenylamino)-benzonitrile (458550-48-6)

Guidance literature:

4-methoxyphenyl magnesium bromide; 3-nitrobenzonitrile; In tetrahydrofuran; at -20 ℃; for 2h;

With sodium tetrahydroborate; iron(II) chloride; In tetrahydrofuran; ethanol; at 20 ℃; for 2h; Further stages.;

DOI:10.1021/ja026718r

Reference yield: 58.0%

4-methoxyphenylboronic acid (5720-07-0) + 3-nitrobenzonitrile (619-24-9) → 3-(4-methoxy-phenylamino)-benzonitrile (458550-48-6)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; at 30 ℃; for 48h; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1021/acs.orglett.1c03343

upstream raw materials:

4-methoxyphenyl magnesium bromide

3-nitrobenzonitrile

4-chloromethoxybenzene

m-cyanoaniline

Refernces

• 1、 -. "HISTONE DEMETHYLASE INHIBITORS". Paragraph 00154; 00155; 00283. . Retrieved 2016/04/09.
• 2、 Sapountzis, Ioannis,Knochel, Paul. "A new general preparation of polyfunctional diarylamines by the addition of functionalized arylmagnesium compounds to nitroarenes". . p. 9390 - 9391. Retrieved 2007/10/03.