Technology Process of 1,3-Dichloro-6,7-dimethoxyisoquinoline
There total 7 articles about 1,3-Dichloro-6,7-dimethoxyisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
P,P-dichlorophenylphosphine oxide;
at 160 ℃;
for 3h;
Sealed tube;
DOI:10.1039/c7md00052a
- Guidance literature:
-
Multi-step reaction with 6 steps
1: n-Butyl nitrite; hydrogenchloride / methanol; water / 0.25 h / 0 °C
2: sodium hydroxide; p-toluenesulfonyl chloride / water / 0.25 h / 20 - 80 °C
3: potassium carbonate / water-d2 / 2 h / 20 °C
4: sodium hydride / 3 h / 20 - 80 °C
5: hydrogenchloride / methanol; water / 1 h / 100 °C
6: P,P-dichlorophenylphosphine oxide / 3 h / 160 °C / Sealed tube
With
P,P-dichlorophenylphosphine oxide; hydrogenchloride; n-Butyl nitrite; sodium hydride; potassium carbonate; p-toluenesulfonyl chloride; sodium hydroxide;
In
methanol; water; water-d2;
DOI:10.1039/c7md00052a
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydroxide; p-toluenesulfonyl chloride / water / 0.25 h / 20 - 80 °C
2: potassium carbonate / water-d2 / 2 h / 20 °C
3: sodium hydride / 3 h / 20 - 80 °C
4: hydrogenchloride / methanol; water / 1 h / 100 °C
5: P,P-dichlorophenylphosphine oxide / 3 h / 160 °C / Sealed tube
With
P,P-dichlorophenylphosphine oxide; hydrogenchloride; sodium hydride; potassium carbonate; p-toluenesulfonyl chloride; sodium hydroxide;
In
methanol; water; water-d2;
DOI:10.1039/c7md00052a
