4-(Trifluoromethyl)-1-indanone

Base Information

• Chemical Name: 4-(Trifluoromethyl)-1-indanone
• CAS No.: 68755-42-0
• Molecular Formula: C10H7F3O
• Molecular Weight: 200.15719 [g/mol]
• Hs Code.: 2914700090
• Mol file: 68755-42-0.mol

Synonyms:4-(Trifluoromethyl)-1-indanone;4-(trifluoroMethyl)-2,3-dihydro-1H-inden-1-one;4-TrifluoroMethyl-indan-1-one;1H-Inden-1-one, 2,3-dihydro-4-(trifluoroMethyl)-;2,3-Dihydro-4-(trifluoromethyl)-1H-inden-1-one, 2,3-Dihydro-1-oxo-4-(trifluoromethyl)-1H-indene

Chemical Property of 4-(Trifluoromethyl)-1-indanone

Chemical Property:

• Vapor Pressure: 0.0566mmHg at 25°C
• Melting Point: 38-42 °C
• Refractive Index: 1.497
• Boiling Point: 233.2 °C at 760 mmHg
• Flash Point: 94 °C
• PSA: 17.07000
• Density: 1.347 g/cm³
• LogP: 2.83430
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Trifluoromethyl)-1-indanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 4-(Trifluoromethyl)-1-indanone

There total 3 articles about 4-(Trifluoromethyl)-1-indanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon monoxide (201230-82-2) + trimethyl((2-(trifluoromethyl)phenyl)ethynyl)silane (40230-94-2) → 4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-one (68755-42-0)

Guidance literature:

With water; triethylamine; triphenylphosphine; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In tetrahydrofuran; at 160 ℃; under 20686.5 Torr;

DOI:10.1021/jm701007g

Reference yield:

trifluoro-methane sulphonic acid + 3-(2-(trifluoromethyl)phenyl)propanoic acid (94022-99-8) → 4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-one (68755-42-0)

Guidance literature:

With sodium carbonate; magnesium sulfate; In thionyl chloride; n-heptane; dichloromethane; ethyl acetate;

Reference yield:

→ 4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-one (68755-42-0)

Guidance literature:

aus der entspr. Phenylpropinsaeure;

upstream raw materials:

3-(2-(trifluoromethyl)phenyl)propanoic acid

carbon monoxide

trimethyl((2-(trifluoromethyl)phenyl)ethynyl)silane

Refernces

• 1、 -. "Acylated indanyl amines and their use as pharmaceuticals". . . Retrieved 2008/06/13.