GSK1070916

Base Information

• Chemical Name: GSK1070916
• CAS No.: 942918-07-2
• Molecular Formula: C30H33N7O
• Molecular Weight: 507.638
• Mol file: 942918-07-2.mol

Synonyms:GSK 1070916

Chemical Property of GSK1070916

Chemical Property:

• PKA: 13.17±0.40(Predicted)
• PSA: 82.08000
• Density: 1.21
• LogP: 6.00840
• Solubility.: ≥25.4 mg/mL in DMSO

Purity/Quality:

98%Min ^*data from raw suppliers

GSK1070916 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: GSK 1070916 is a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models.

Technology Process of GSK1070916

There total 3 articles about GSK1070916 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N'-(4-{1-ethyl-4-[2-(3-formylphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-N,N-dimethylurea (942918-99-2) + dimethyl amine (124-40-3) → GSK1070916 (942918-07-2)

Guidance literature:

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield: 46.0%

4-[3-(4-aminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(dimethylaminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine (942919-53-1) + dimethyl amine (124-40-3) → GSK1070916 (942918-07-2)

Guidance literature:

4-[3-(4-aminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(dimethylaminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine; 4-Nitrophenyl chloroformate; In tetrahydrofuran; at 20 ℃; for 1h;

dimethyl amine; In tetrahydrofuran; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield:

C34H31N7O4 + dimethyl amine (124-40-3) → GSK1070916 (942918-07-2)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1021/jm901870q

upstream raw materials:

4-[3-(4-aminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(dimethylaminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine

dimethyl amine

N'-(4-{1-ethyl-4-[2-(3-formylphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-N,N-dimethylurea

Refernces

• 1、 -. "AZAINDOLE INHIBITORS OF AURORA KINASES". Page/Page column 72. . Retrieved 2008/06/13.