Glycine 1-methylethyl ester

Base Information

• Chemical Name: Glycine 1-methylethyl ester
• CAS No.: 13048-66-3
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.148
• Hs Code.: 2922499990
• Mol file: 13048-66-3.mol

Synonyms:Glycine,isopropyl ester (6CI,7CI,8CI);Isopropyl glycinate;

Chemical Property of Glycine 1-methylethyl ester

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 10.957mmHg at 25°C
• Refractive Index: 1.427
• Boiling Point: 127.78 °C at 760 mmHg
• PKA: 7.65±0.29(Predicted)
• Flash Point: 3.533 °C
• PSA: 52.32000
• Density: 0.988 g/cm³
• LogP: 0.59700

Purity/Quality:

99% ^*data from raw suppliers

PROPAN-2-YL-2-AMINOACETATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine 1-methylethyl ester

There total 3 articles about Glycine 1-methylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-Boc-glycine isopropylester (197579-95-6) → glycine isopropyl ester (13048-66-3)

Guidance literature:

With methanol; 2-Bromoacetyl bromide; In dichloromethane; at 25 ℃; for 0.333333h;

DOI:10.1055/s-2002-19803

Reference yield: 60.0%

glycine isopropyl ester hydrochloride (14019-62-6) → glycine isopropyl ester (13048-66-3)

Guidance literature:

With ammonium hydroxide; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1039/c7ra00073a

Reference yield: 53.0%

isopropyl alcohol (67-63-0,8013-70-5) + glycine (56-40-6,18875-39-3,25718-94-9) → glycine isopropyl ester (13048-66-3)

Guidance literature:

With sulfuric acid; for 12h; Reflux;

DOI:10.1016/j.molstruc.2013.03.012

upstream raw materials:

isopropyl alcohol

glycine

N-Boc-glycine isopropylester

glycine isopropyl ester hydrochloride

Downstream raw materials:

C₁₂H₁₅NO₂

C₂₇H₂₅F₃N₄O₄

isopropyl chloroacetate

1-(4-[N-(2-iso-propyloxy-2-oxoethylcarbamoyl)aminomethyl]-3-methylbenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Refernces

• 1、 Quevedo, Rodolfo,Pabón, Laura,Quevedo-Acosta, Yovanny. "1H NMR study on the intermolecular interactions of macrocyclic and single α-Amino acids". . p. 68 - 72. Retrieved 2013.
• 2、 Biancalana, Lorenzo,Bortoluzzi, Marco,Ferretti, Eleonora,Hayatifar, Mohammad,Marchetti, Fabio,Pampaloni, Guido,Zacchini, Stefano. "The reactions of α-amino acids and α-amino acid esters with high valent transition metal halides: synthesis of coordination complexes, activation processes and stabilization of α-ammonium acylchloride cations". . p. 10158 - 10174. Retrieved 2017/02/15.
• 3、 Dunn, Philip J. H.,Honch, Noah V.,Evershed, Richard P.. "Comparison of liquid chromatography-isotope ratio mass spectrometry (LC/IRMS) and gas chromatography-combustion-isotope ratio mass spectrometry (GC/C/IRMS) for the determination of collagen amino acid δ13C values for palaeodietary and palaeoecological reconstruction". experimental part. p. 2995 - 3011. Retrieved 2012/05/20.