Imidazo[2,1-b]thiazole-5-carboxylic acid

Base Information

• Chemical Name: Imidazo[2,1-b]thiazole-5-carboxylic acid
• CAS No.: 17782-81-9
• Molecular Formula: C6H4N2O2S
• Molecular Weight: 168.176
• Hs Code.: 2934100090
• Mol file: 17782-81-9.mol

Synonyms:Imidazo[2,1-b][1,3]thiazole-5-carboxylic acid;Imidazo[2,1-b]thiazole-5-carboxylic acid;Imidazo[2,1-b]thiazole-5-carboxylicacid;LogP

Chemical Property of Imidazo[2,1-b]thiazole-5-carboxylic acid

Chemical Property:

• Refractive Index: 1.808
• PKA: -0.72±0.41(Predicted)
• PSA: 82.84000
• Density: 1.74g/cm³
• LogP: 1.09400
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Imidazo[2,1-b]thiazole-5-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[2,1-b]thiazole-5-carboxylic acid

There total 4 articles about Imidazo[2,1-b]thiazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

imidazo[2,1-b]thiazole-5-carboxylic acid ethyl ester (349480-83-7) → imidazo[2,1-b]thiazole-5-carboxylic acid (17782-81-9)

Guidance literature:

imidazo[2,1-b]thiazole-5-carboxylic acid ethyl ester; With sodium hydroxide; water; In tetrahydrofuran; methanol; for 16h;

With hydrogenchloride; In water; at 0 ℃; pH=3 - 4;

Reference yield:

2-(dimethylamino-methyleneamino)-3-ethoxycarbonylmethyl-thiazol-3-ium bromide (1038509-26-0) → imidazo[2,1-b]thiazole-5-carboxylic acid (17782-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 20 h / 20 °C

2.1: methanol; sodium hydroxide; water / tetrahydrofuran / 20 h / 20 °C

2.2: 0 °C / pH 3 - 4

With methanol; sodium hydroxide; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

imidazo[2,1-b]thiazole-5-carboxylic acid methyl ester (96583-38-9) → imidazo[2,1-b]thiazole-5-carboxylic acid (17782-81-9)

Guidance literature:

With hydrogenchloride;

DOI:10.1007/BF00478394

upstream raw materials:

imidazo[2,1-b]thiazole-5-carboxylic acid methyl ester

imidazo[2,1-b]thiazole-5-carboxylic acid ethyl ester

2-(dimethylamino-methyleneamino)-3-ethoxycarbonylmethyl-thiazol-3-ium bromide

Downstream raw materials:

imidazo[2,1-b]thiazole-5-carboxylic acid {(1S,3S,5S)-2-[5-(3-fluoro-phenyl)-2-methyl-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide

imidazo(2,1-b)thiazole

Refernces

• 1、 -. "3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES". Page/Page column 46. . Retrieved 2010/02/17.
• 2、 -. "TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES". Page/Page column 81. . Retrieved 2009/03/07.