5-Pyrimidinecarboxylic acid, 1,4-dihydro-4-oxo- (9CI)

Base Information

• Chemical Name: 5-Pyrimidinecarboxylic acid, 1,4-dihydro-4-oxo- (9CI)
• CAS No.: 65754-04-3
• Molecular Formula: C₅H₄N₂O₃
• Molecular Weight: 140.098
• Hs Code.: 2933599090
• Mol file: 65754-04-3.mol

Synonyms:6-oxo-1H-pyrimidine-5-carboxylic acid

Chemical Property of 5-Pyrimidinecarboxylic acid, 1,4-dihydro-4-oxo- (9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 238 °C (decomp)
• Boiling Point: 364.482oC at 760 mmHg
• PKA: 3.19±0.20(Predicted)
• Flash Point: 174.233ºC
• PSA: 83.31000
• Density: 1.613g/cm3
• LogP: -0.11960
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

96% 1H NMR ^*data from raw suppliers

4-Hydroxypyrimidine-5-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Hydroxypyrimidine-5-carboxylic acid

Technology Process of 5-Pyrimidinecarboxylic acid, 1,4-dihydro-4-oxo- (9CI)

There total 5 articles about 5-Pyrimidinecarboxylic acid, 1,4-dihydro-4-oxo- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium salt of methyl 4-hydroxypyrimidine-5-carboxylate → 4-Hydroxy-5-carboxy-pyrimidin (65754-04-3)

Guidance literature:

In water;

Reference yield:

ethyl 2,4-dichloropyrimidine-5-carboxylate (51940-64-8) → 6-oxo-1,6-dihydro-pyrimidine-5-carboxylic acid (65754-04-3)

Guidance literature:

With phosphorus; water; hydrogen iodide; acetic acid;

DOI:10.1021/ja01256a016

Reference yield:

ethyl 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxilate (38026-46-9) → 6-oxo-1,6-dihydro-pyrimidine-5-carboxylic acid (65754-04-3)

Guidance literature:

With water; nickel;

upstream raw materials:

ethyl 2,4-dichloropyrimidine-5-carboxylate

ethyl 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxilate

Refernces

• 1、 -. "Heterocyclic mutilin esters and their use as antibacterials". . . Retrieved 2008/06/13.
• 2、 -. "Process for preparing substituted pyrimidine derivatives". . . Retrieved 2008/06/13.