6-Bromo-1H-pyrrolo[3,2-b]pyridine

Base Information

• Chemical Name: 6-Bromo-1H-pyrrolo[3,2-b]pyridine
• CAS No.: 944937-53-5
• Molecular Formula: C7H5BrN2
• Molecular Weight: 197.034
• Hs Code.: 2933990090
• Mol file: 944937-53-5.mol

Synonyms:6-Bromo-1H-pyrrolo[3,2-b]pyridine;

Chemical Property of 6-Bromo-1H-pyrrolo[3,2-b]pyridine

Chemical Property:

• Vapor Pressure: 0.00104mmHg at 25°C
• Refractive Index: 1.727
• Boiling Point: 311.3 °C at 760 mmHg
• PKA: 13.73±0.40(Predicted)
• Flash Point: 142.1 °C
• PSA: 28.68000
• Density: 1.77 g/cm³
• LogP: 2.32540
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99.0% ^*data from raw suppliers

6-Bromo-1H-pyrrolo[3,2-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Bromo-1H-pyrrolo[3,2-b]pyridine is used in the preparation of benzofuran and pyridine compounds in the treatment of viral diseases, respiratory illnesses, inflammatory diseases.

Technology Process of 6-Bromo-1H-pyrrolo[3,2-b]pyridine

There total 1 articles about 6-Bromo-1H-pyrrolo[3,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-chloro-3-nitropyridine (67443-38-3) → 6-bromo-1H-pyrrolo[3,2-b]pyrridine (944937-53-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-aniline / 0.17 h / Inert atmosphere

1.2: 3 h / 40 °C

2.1: hydrogenchloride; water / 5 h / Reflux

3.1: N,N-dimethyl-formamide / 4.25 h / 90 °C / Inert atmosphere

4.1: acetic acid; iron / 100 °C

With hydrogenchloride; water; iron; sodium hydride; acetic acid; In N,N-dimethyl-aniline; N,N-dimethyl-formamide;

Reference yield: 99.0%

6-bromo-1H-pyrrolo[3,2-b]pyrridine (944937-53-5) + benzenesulfonyl chloride (98-09-9) → 6-bromo-1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine

Guidance literature:

6-bromo-1H-pyrrolo[3,2-b]pyrridine; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.25h;

benzenesulfonyl chloride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 18h;

Reference yield: 98.0%

6-bromo-1H-pyrrolo[3,2-b]pyrridine (944937-53-5) + 4-fluoroboronic acid (1765-93-1) → 6-(4-fluorophenyl)-1H-pyrrolo[3.2-b]pyridine

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 90 ℃; for 16h;

upstream raw materials:

5-bromo-2-chloro-3-nitropyridine

Downstream raw materials:

6-bromo-1-methyl-1H-pyrrolo[3,2-b]pyridine

(S)-5,5-dimethyl-4-phenyl-3-(1-(1-(pyrimidin-2-yl)-1H-pyrrolo[3,2-b]pyridin-6-yl)piperidin-4-yl)oxazolidin-2-one

(S)-5,5-dimethyl-4-phenyl-3-((S)-4-(1-(pyrimidin-2-yl)-1H-pyrrolo[3,2-b]pyridin-6-yl)cyclohex-3-en-1-yl)oxazolidin-2-one

(S)-5,5-dimethyl-4-phenyl-3-((R)-4-(1-(pyrimidin-2-yl)-1H-pyrrolo[3,2-b]pyridin-6-yl)cyclohex-3-en-1-yl)oxazolidin-2-one

Refernces

• 1、 -. "SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES". . . Retrieved 2013/03/26.