Dutogliptin tartrate

Base Information Edit

Chemical Name:Dutogliptin tartrate
CAS No.:890402-81-0
Deprecated CAS:898546-83-3
Molecular Formula:C14H26BN3O9
Molecular Weight:391.186
Hs Code.:
UNII:79QH89EV9M
DSSTox Substance ID:DTXSID301008624
NCI Thesaurus Code:C87493
Wikidata:Q27266774
Mol file:890402-81-0.mol

Synonyms:Dutogliptin tartrate;890402-81-0;Dutogliptin tartrate [USAN];Dutogliptin (tartrate);79QH89EV9M;890402-81-0 (tartratet);Dutogliptin tartrate (USAN);(2R,3R)-2,3-dihydroxysuccinic acid compound with ((R)-1-(((R)-pyrrolidin-3-yl)glycyl)pyrrolidin-2-yl)boronic acid (1:1);PHX-1149;(2R,3R)-2,3-dihydroxybutanedioic acid;[(2R)-1-[2-[[(3R)-pyrrolidin-3-yl]amino]acetyl]pyrrolidin-2-yl]boronic acid;PHX1149T;UNII-79QH89EV9M;PHX 1149;PHX-1149T;DTXSID301008624;HY-10286A;AKOS040733046;CS-0034603;D09334;Q27266774;((R)-1-(((R)-pyrrolidin-3-yl)glycyl)pyrrolidin-2-yl)boronic acid (2R,3R)-2,3-Dihydroxysuccinic acid salt;[(2R)-1-{N-[(3R)-Pyrrolidin-3-yl]glycyl}pyrrolidin-2-yl]boronic acid (2R,3R)-2,3-dihydroxybutanedioate (1:1);2,3-Dihydroxybutanedioic acid--{1-[N-(pyrrolidin-3-yl)glycyl]pyrrolidin-2-yl}boronic acid (1/1);Boronic acid, ((2R)-1-(((3R)-3-pyrrolidinylamino)acetyl)-2-pyrrolidinyl)-, (2R,3R)-2,3-dihydroxybutanedioate (1:1);BORONIC ACID, ((2R)-1-(((3R)-3-PYRROLIDINYLAMINO)ACETYL)-2-PYRROLIDINYL)-, (2R,3R)-2,3-DIHYDROXYBUTANEDIOATE (1:1)

Suppliers and Price of Dutogliptin tartrate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemtos
DutogliptinTartrate
10 mg
$ 1990.00

Total 2 raw suppliers

Chemical Property of Dutogliptin tartrate Edit

Chemical Property:

PSA：199.89000
LogP:-3.10420
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:7
Exact Mass:391.1762096
Heavy Atom Count:27
Complexity:411

Purity/Quality:

99% ^*data from raw suppliers

DutogliptinTartrate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:B(C1CCCN1C(=O)CNC2CCNC2)(O)O.C(C(C(=O)O)O)(C(=O)O)O
Isomeric SMILES:B([C@@H]1CCCN1C(=O)CN[C@@H]2CCNC2)(O)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
Recent ClinicalTrials:Study of Dutogliptin in Combination With Filgrastim in Post-Myocardial Infarction
Recent EU Clinical Trials:A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Safety and Efficacy Study of Dutogliptin in Combination with Filgrastim in Early Recovery Post-Myocardial Infarction

Technology Process of Dutogliptin tartrate

There total 5 articles about Dutogliptin tartrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.5%

: 890402-81-0
dutogliptin-L-tartrate

Guidance literature:

Reference yield: 85.0%

: 923566-03-4
(2R)-1-{2-[(3R)-pyrrolidinylamino]-acetyl}-pyrrolidine-2-boronic acid (1S,2S,3R,5S)-pinanediol ester

: 87-69-4,138508-61-9
L-Tartaric acid

: 890402-81-0
dutogliptin-L-tartrate

Guidance literature:: (2R)-1-{2-[(3R)-pyrrolidinylamino]-acetyl}-pyrrolidine-2-boronic acid (1S,2S,3R,5S)-pinanediol ester; L-Tartaric acid; In water; at 20 ℃; for 2h; Large scale;

With phenylboronic acid; In hexane; water; for 3h; Time; Large scale;