2-Amino-5-bromobenzaldehyde

Base Information

• Chemical Name: 2-Amino-5-bromobenzaldehyde
• CAS No.: 29124-57-0
• Molecular Formula: C7H6BrNO
• Molecular Weight: 200.035
• Hs Code.: 2922399090
• Mol file: 29124-57-0.mol

Synonyms:2-Amino-5-bromobenzaldehyde;Anthranilaldehyde,5-bromo- (8CI);

Chemical Property of 2-Amino-5-bromobenzaldehyde

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 75-77°C
• Refractive Index: 1.675
• Boiling Point: 290.267 °C at 760 mmHg
• PKA: -0.35±0.10(Predicted)
• Flash Point: 129.349 °C
• PSA: 43.09000
• Density: 1.673g/cm³
• LogP: 2.42500
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Sensitive.: Air Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-5-bromobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Participate in synthesis and structure activity of novel camptothecin analogs.

Technology Process of 2-Amino-5-bromobenzaldehyde

There total 10 articles about 2-Amino-5-bromobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-bromo-2-nitrobenzaldehyde (20357-20-4) → 2-amino-5-bromobenzaldehyde (29124-57-0)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; at 100 ℃; for 1.5h;

DOI:10.1055/s-2008-1067148

Reference yield: 97.0%

(2-amino-5-bromophenyl)methanol (20712-12-3) → 2-amino-5-bromobenzaldehyde (29124-57-0)

Guidance literature:

With 1-methyl-1H-imidazole; [2,2]bipyridinyl; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetrakisacetonitrile copper(I) trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 2h;

DOI:10.15227/orgsyn.090.0240

Reference yield: 87.0%

→ 2-amino-5-bromobenzaldehyde (29124-57-0)

Guidance literature:

upstream raw materials:

o-aminobenzaldehyde

5-bromo-2-nitrobenzaldehyde

N,N-dimethyl-formamide

4-bromo-aniline

Downstream raw materials:

2-amino-6-bromo-3-cyanoquinoline

6-bromo-2-(4'-chloro-4-methoxy-biphenyl-2-yl)-quinoline

6-bromo-2-thiazol-5-ylquinoline

4-bromo-2-formylphenylformamide

Refernces

• 1、 Zhu, Xiaolin,Lystrom, Levi,Kilina, Svetlana,Sun, Wenfang. "Tuning the photophysics and reverse saturable absorption of heteroleptic cationic iridium(III) complexes via substituents on the 6,6′-bis(fluoren-2-yl)-2,2′-biquinoline ligand". . p. 11908 - 11919. Retrieved 2016.
• 2、 Cui, Peng,Kilina, Svetlana,Lu, Cuifen,Lu, Taotao,Sun, Wenfang. "Photophysics and reverse saturable absorption of cationic dinuclear iridium(iii) complexes bearing fluorenyl-tethered 2-(quinolin-2-yl)quinoxaline ligands". . p. 14309 - 14319. Retrieved 2021/10/25.
• 3、 Laraia, Luca,Olsen, Asger Hegelund,Whitmarsh-Everiss, Thomas. "Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol-Inspired Compound Collection". supporting information. p. 26755 - 26761. Retrieved 2021/11/17.